Review Article

Paternal Smoking and Risk of Childhood Acute Lymphoblastic Leukemia: Systematic Review and Meta-Analysis

Table 3

Summary of the five studies detangling effect of paternal smoking from maternal smoking on childhood ALL.

StudyExposure to parental smokingNumber of case/controlOR (95% CI)Adjustments
Paternal smokingMaternal smoking

Lee et al. 2009, Korea [42]* Ever smoked cigarettesAdjusted for age, sex, birth weight, father's education
 Lifetime nonsmokersLifetime nonsmokers22/41reference
 everlifetime nonsmokers84/1221.3 (0.7, 2.4)
pack-years before pregnancy
 0lifetime nonsmokers22/41reference
 ≤10lifetime nonsmokers48/601.6 (0.8, 3.1)
 >10lifetime nonsmokers28/331.6 (0.8, 3.5)
Smoking at home during pregnancy
 Lifetime nonsmokerslifetime nonsmokers22/41reference
 yeslifetime nonsmokers22/222.1 (0.9, 4.9)
pack-years after birth
 0lifetime nonsmokers27/55reference
 ≤10lifetime nonsmokers64/771.7 (0.9, 3.1)
>10lifetime  nonsmokers11/113.0 (1.0, 8.8)

Ji et al. 1997, China [41] pack-years before pregnancyAdjusted for birth weight, income, paternal age, education, and alcohol drinking
 0lifetime nonsmokersreference
 ≤2lifetime nonsmokers0.8 (0.2–2.5)
 2 to 5lifetime nonsmokers1.0 (0.4–2.7)
≥5Lifetime  nonsmokers3.8 (1.3–12.3)
Pack-years after pregnancy
 0lifetime nonsmokersreference
 ≤2lifetime nonsmokers1.1 (0.4, 2.8)
 2 to 5lifetime nonsmokers1.8 (0.6, 5.2)
 ≥5lifetime nonsmokers1.8 (0.6, 5.5)

Chang et al. 2006, USA [23]No preconception smokingno postnatal smoking144/205referencehousehold income and maternal smoking during preconception and pregnancy
No preconception smokingpostnatal smoking8/270.72 (0.22, 2.38)
Preconception smokingno postnatal smoking36/470.88 (0.51, 1.52)
Preconception  smokingpostnatal  smoking37/233.94 (1.25, 12.37)

Brondum et al. 1999, USA [21]Never smoked in the homenever smoking in the homereferenceAdjusted for household income, mother's and father's race and education
Never smoked in the homeever smoked in the home1.10 (0.88, 1.38)
Ever smoked in the homenever smoking in the home1.04 (0.86, 1.26)
Ever smoked in the homeever smoked in the home1.09 (0.91, 1.30)

John et al. 1991, USA [27]Not during the year prior to birthnot during the 1st trimesterreferenceAdjusted for father's education
Not during the year prior to birthyes, during the 1st trimester1.9 (0.9, 4.1)
Yes, during the year prior to birthnot during the 1st trimester1.4 (0.6, 3.1)
Yes, during the year prior to birthyes, during the 1st trimester1.8 (0.8, 4.0)

*It was reported that small portion of mothers smoked (the smoking rate was 6.1% for controls' mothers; it was not reported for cases’ mothers).