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Journal of Oncology
Volume 2011, Article ID 875959, 7 pages
Review Article

Role of Brush Biopsy and DNA Cytometry for Prevention, Diagnosis, Therapy, and Followup Care of Oral Cancer

1Institute of Cytopathology, Heinrich-Heine-University, Moorenstraße 5, 40225 Düsseldorf, Germany
2Department for Cranio- and Maxillofacial Surgery, Heinrich-Heine-University, Moorenstraße 5, 40225 Düsseldorf, Germany
3Department of General, Visceral, and Pediatric Surgery, University Hospital Düsseldorf, Heinrich-Heine-University, 40225 Düsseldorf, Germany

Received 30 September 2010; Accepted 21 November 2010

Academic Editor: Pankaj Chaturvedi

Copyright © 2011 Alfred Böcking et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Late diagnosis resulting in late treatment and locoregional failure after surgery are the main causes of death in patients with oral squamous cell carcinomas (SCCs). Actually, exfoliative cytology is increasingly used for early detection of oral cancer and has been the subject of intense research over the last five years. Significant advances have been made both in relation to screening and evaluation of precursor lesions. As this noninvasive procedure is well tolerated by patients, more lesions may be screened and thus more oral cancers may be found in early, curable stages. Moreover, the additional use of DNA image cytometry is a reasonable tool for the assessment of the resection margins of SCC. DNA image cytometry could help to find the appropriate treatment option for the patients. Finally, diagnostic DNA image cytometry is an accurate method and has internationally been standardized. In conclusion, DNA image cytometry has increasing impact on the prevention, diagnostic, and therapeutical considerations in head and neck SCC.