Hypermethylation of CCND2 May Reflect a Smoking-Induced Precancerous Change in the Lung

Table 1

Genes hypermethylated in >2% of noncancerous lung tissues.

HUGO acronym	Gene name	Function
APC	Adenomatous polyposis coli	Cell cycle: inhibits WNT signaling pathway, involved in spindle assembly and chromosome segregation, cell adhesion, and cell migration [38].
CCND2	Cyclin D2	Cell cycle: regulates entry into S-phase with CDK4 and CDK6 [39]
CDH1	Cadherin 1; e-cadherin (epithelial)	Cell adhesion, epithelial-mesenchymal transition [40]
RARB	Retinoic acid receptor, beta	Regulation of cell proliferation and differentiation [41]