Toll-Like Receptor 7 Agonist Therapy with Imidazoquinoline Enhances Cancer Cell Death and Increases Lymphocytic Infiltration and Proinflammatory Cytokine Production in Established Tumors of a Renal Cell Carcinoma Mouse Model
Figure 3
3M011 reduces RCC tumor growth in mice. RENCA RCC xenografts in mice () were treated on day 0 and day 7 with 3M011 imidazoquinoline or placebo. (a) Tumor growth following 3M011 versus placebo treatment on day 0. (b) Tumor growth following retreatment with 3M011 versus placebo on day 7 in mice receiving placebo on day 0. (c) Tumor growth following retreatment with 3M011 versus placebo on day 7 in mice receiving 3M011 on day 0. (d) Mean weights of tumors harvested on day 9 based on day 0/day 7 treatment. *; **; ***; ****; ‡; error bars = standard error of the mean.