Research Article

Toll-Like Receptor 7 Agonist Therapy with Imidazoquinoline Enhances Cancer Cell Death and Increases Lymphocytic Infiltration and Proinflammatory Cytokine Production in Established Tumors of a Renal Cell Carcinoma Mouse Model

Figure 3

3M011 reduces RCC tumor growth in mice. RENCA RCC xenografts in mice ( 𝑁 = 2 8 ) were treated on day 0 and day 7 with 3M011 imidazoquinoline or placebo. (a) Tumor growth following 3M011 versus placebo treatment on day 0. (b) Tumor growth following retreatment with 3M011 versus placebo on day 7 in mice receiving placebo on day 0. (c) Tumor growth following retreatment with 3M011 versus placebo on day 7 in mice receiving 3M011 on day 0. (d) Mean weights of tumors harvested on day 9 based on day 0/day 7 treatment. * 𝑃 < 0 . 0 0 1 ; ** 𝑃 < 0 . 0 1 ; *** 𝑃 < 0 . 0 5 ; **** 𝑃 < 0 . 1 0 ; 𝑃 = 0 . 4 5 ; error bars = standard error of the mean.
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