Angiogenesis in Acute Myeloid Leukemia and Opportunities for Novel Therapies

Figure 1

Acute Myeloid Leukemia Cells Within the Bone Marrow Microenvironment. The bone marrow niche can be simplistically divided into the endosteal niche or osteoblastic niche which is located on the inner bone surface. Hematopoietic stem cells (HSCs) have been found to reside here in a quiescent state. The vascular niche is made up a central sinusoid and lined by endothelial cells, macrophages, and perivascular cells. In the central marrow region, between the endosteal niche and vascular niche, acute myeloid leukemia (AML) cells hijiack the entire bone marrow anatomy and induce angiogenesis. The location of AML initiation and relapse within the bone marrow has yet to be defined.