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Journal of Oncology
Volume 2012 (2012), Article ID 141236, 11 pages
http://dx.doi.org/10.1155/2012/141236
Review Article

The Role of PTEN in Tumor Angiogenesis

Department of Clinical Research and Department of Nephrology and Hypertension, Inselspital, University of Bern Medical School, 3010 Bern, Switzerland

Received 20 April 2011; Accepted 1 July 2011

Academic Editor: Sundaram Ramakrishnan

Copyright © 2012 Stéphane Rodriguez and Uyen Huynh-Do. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

During the past 20 years, the phosphatase and tensin homolog PTEN has been shown to be involved in major physiological processes, and its mutation or loss is often associated with tumor formation. In addition PTEN regulates angiogenesis not only through its antagonizing effect on the PI3 kinase pathway mainly, but also through some phosphatase-independent functions. In this paper we delineate the role of this powerful tumor suppressor in tumor angiogenesis and dissect the underlying molecular mechanisms. Furthermore, it appears that, in a number of cancers, the PTEN status determines the response to chemotherapy, highlighting the need to monitor PTEN expression and to develop PTEN-targeted therapies.