Table of Contents Author Guidelines Submit a Manuscript
Journal of Oncology
Volume 2012 (2012), Article ID 280386, 8 pages
http://dx.doi.org/10.1155/2012/280386
Research Article

The Adipocyte-Derived Hormone Leptin Has Proliferative Actions on Androgen-Resistant Prostate Cancer Cells Linking Obesity to Advanced Stages of Prostate Cancer

Clinic for Urology and Kidney Transplantation Centre, University Medical School of Halle/Wittenberg, Ernst-Grube-Strasse 40, 06120 Halle, Saale, Germany

Received 29 December 2011; Revised 22 February 2012; Accepted 29 March 2012

Academic Editor: Michael Carducci

Copyright © 2012 M. Raschid Hoda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. K. Carroll, “Obesity as a risk factor for certain types of cancer,” Lipids, vol. 33, no. 11, pp. 1055–1059, 1998. View at Google Scholar · View at Scopus
  2. G. A. Bray, “The underlying basis for obesity: relationship to cancer,” Journal of Nutrition, vol. 132, no. 11, supplement, pp. 3451S–3455S, 2002. View at Google Scholar · View at Scopus
  3. S. J. Freeland and W. J. Aronson, “Examining the relationship between obesity and prostate cancer,” Reviews in Urology, vol. 6, pp. 73–81, 2004. View at Google Scholar
  4. S. O. Andersson, A. Wolk, R. Bergström et al., “Body size and prostate cancer: a 20-year follow-up study among 135 006 Swedish construction workers,” Journal of the National Cancer Institute, vol. 89, no. 5, pp. 385–389, 1997. View at Google Scholar · View at Scopus
  5. T. Mistry, J. E. Digby, J. Chen, K. M. Desai, and H. S. Randeva, “The regulation of adiponectin receptors in human prostate cancer cell lines,” Biochemical and Biophysical Research Communications, vol. 348, no. 3, pp. 832–838, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. S. J. Freedland, “Obesity and prostate cancer: a growing problem,” Clinical Cancer Research, vol. 11, no. 19 I, pp. 6763–6766, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Baillargeon, E. A. Platz, D. P. Rose et al., “Obesity, adipokines, and prostate cancer in a prospective population-based study,” Cancer Epidemiology Biomarkers and Prevention, vol. 15, no. 7, pp. 1331–1335, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. S. J. Freedland, L. J. Sokoll, E. A. Platz et al., “Association between serum adiponectin, and pathological stage and grade in men undergoing radical prostatectomy,” Journal of Urology, vol. 174, no. 4 I, pp. 1266–1270, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. K. A. Frankenberry, P. Somasundar, D. W. McFadden, and L. C. Vona-Davis, “Leptin induces cell migration and the expression of growth factors in human prostate cancer cells,” American Journal of Surgery, vol. 188, no. 5, pp. 560–565, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. Z. Zhu, W. Jiang, and H. J. Thompson, “An experimental paradigm for studying the cellular and molecular mechanisms of cancer inhibition by energy restriction,” Molecular Carcinogenesis, vol. 35, no. 2, pp. 51–56, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. D. Berrigan, S. N. Perkins, D. C. Haines, and S. D. Hursting, “Adult-onset calorie restriction and fasting delay spontaneous tumorigenesis in p53-deficient mice,” Carcinogenesis, vol. 23, no. 5, pp. 817–822, 2002. View at Google Scholar · View at Scopus
  12. V. Mai, L. H. Colbert, D. Berrigan et al., “Calorie restriction and diet composition modulate spontaneous intestinal tumorigenesis in ApcMin mice through different mechanisms,” Cancer Research, vol. 63, no. 8, pp. 1752–1755, 2003. View at Google Scholar · View at Scopus
  13. J. M. Friedman and J. L. Halaas, “Leptin and the regulation of body weight in mammals,” Nature, vol. 395, no. 6704, pp. 763–770, 1998. View at Publisher · View at Google Scholar · View at Scopus
  14. R. S. Ahlma, D. Prabakaran, C. Mantzoros et al., “Role of leptin in the neuroendocrine response to fasting,” Nature, vol. 382, no. 6588, pp. 250–252, 1996. View at Publisher · View at Google Scholar · View at Scopus
  15. W. F. Blum, P. Englaro, A. M. Attanasio, W. Kiess, and W. Rascher, “Human and clinical perspectives on leptin,” Proceedings of the Nutrition Society, vol. 57, no. 3, pp. 477–485, 1998. View at Google Scholar · View at Scopus
  16. J. C. H. Hardwick, G. R. Van Den Brink, G. J. Offerhaus, J. H. Van Deventer, and M. P. Peppelenbosch, “Leptin is a growth factor for colonic epithelial cells,” Gastroenterology, vol. 121, no. 1, pp. 79–90, 2001. View at Google Scholar · View at Scopus
  17. M. R. Hoda, S. J. Keely, L. S. Bertelsen, W. G. Junger, D. Dharmasena, and K. E. Barrett, “Leptin acts as a mitogenic and antiapoptotic factor for colonic cancer cells,” British Journal of Surgery, vol. 94, no. 3, pp. 346–354, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. J. H. Choi, S. H. Park, C. K. Leung, and K. C. Choi, “Expression of leptin receptors and potential effects of leptin on the cell growth and activation of mitogen-activated protein kinases in ovarian cancer cells,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 1, pp. 207–210, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. K. Laud, I. Gourdou, L. Pessemesse, J. P. Peyrat, and J. Djiane, “Identification of leptin receptors in human breast cancer: functional activity in the T47-D breast cancer cell line,” Molecular and Cellular Endocrinology, vol. 188, no. 1-2, pp. 219–226, 2002. View at Google Scholar · View at Scopus
  20. P. Somasundar, K. A. Frankenberry, H. Skinner et al., “Prostate cancer cell proliferation is influenced by leptin,” Journal of Surgical Research, vol. 118, no. 1, pp. 71–82, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Onuma, J. D. Bub, T. L. Rummel, and Y. Iwamoto, “Prostate cancer cell-adipocyte interaction: leptin mediates androgen-independent prostate cancer cell proliferation through c-Jun NH 2-terminal kinase,” Journal of Biological Chemistry, vol. 278, no. 43, pp. 42660–42667, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. M. R. Hoda and G. Popken, “Mitogenic and anti-apoptotic actions of adipocyte-derived hormone leptin in prostate cancer cells,” BJU International, vol. 102, no. 3, pp. 383–388, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. K. Hegyi, K. Fülöp, K. Kovács, S. Tóth, and A. Falus, “Leptin-induced signal transduction pathways,” Cell Biology International, vol. 28, no. 3, pp. 159–169, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. A. S. Banks, S. M. Davis, S. H. Bates, and M. G. Myers Jr., “Activation of downstream signals by the long form of the leptin receptor,” Journal of Biological Chemistry, vol. 275, no. 19, pp. 14563–14572, 2000. View at Publisher · View at Google Scholar · View at Scopus
  25. W. P. James, “WHO recognition of the global obesity epidemic,” International Journal of Obesity, vol. 32, no. 7, pp. S120–S126, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. E. E. Calle, C. Rodriguez, K. Walker-Thurmond, and M. J. Thun, “Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults,” The New England Journal of Medicine, vol. 348, no. 17, pp. 1625–1638, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. D. P. Rose, E. M. Gilhooly, and D. W. Nixon, “Adverse effects of obesity on breast cancer prognosis, and the biological actions of leptin,” International Journal of Oncology, vol. 21, no. 6, pp. 1285–1292, 2002. View at Google Scholar · View at Scopus
  28. Z. Liu, T. Uesaka, H. Watanabe, and N. Kato, “High fat diet enhances colonic cell proliferation and carcinogenesis in rats by elevating serum leptin,” International Journal of Oncology, vol. 19, no. 5, pp. 1009–1014, 2001. View at Google Scholar · View at Scopus
  29. P. Somasundar, D. W. McFadden, S. M. Hileman, and L. Vona-Davis, “Leptin is a growth factor in cancer,” Journal of Surgical Research, vol. 116, no. 2, pp. 337–349, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. H. Fei, H. J. Okano, C. Li et al., “Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues,” Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 13, pp. 7001–7005, 1997. View at Publisher · View at Google Scholar · View at Scopus
  31. W. Malendowicz, M. Rucinski, A. S. Belloni, A. Ziolkowska, G. G. Nussdorfer, and Z. Kwias, “Real-time PCR analysis of leptin and leptin receptor expression in the rat prostate, and effects of leptin on prostatic acid phosphatase release,” International Journal of Molecular Medicine, vol. 18, no. 6, pp. 1097–1100, 2006. View at Google Scholar · View at Scopus
  32. L. A. Tartaglia, M. Dembski, X. Weng et al., “Identification and expression cloning of a leptin receptor, OB-R,” Cell, vol. 83, no. 7, pp. 1263–1271, 1995. View at Publisher · View at Google Scholar · View at Scopus
  33. W. Malendowicz, M. Rucinski, C. Macchi et al., “Leptin and leptin receptors in the prostate and seminal vesicles of the adult rat,” International Journal of Molecular Medicine, vol. 18, no. 4, pp. 615–618, 2006. View at Google Scholar · View at Scopus
  34. P. Somasundar, A. K. Yu, L. Vona-Davis, and D. W. McFadden, “Differential effects of leptin on cancer in vitro,” Journal of Surgical Research, vol. 113, no. 1, pp. 50–55, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. P. Stattin, S. Söderberg, G. Hallmans et al., “Leptin is associated with increased prostate cancer risk: a nested case-referent study,” Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 3, pp. 1341–1345, 2001. View at Publisher · View at Google Scholar · View at Scopus
  36. R. Gade-Andavolu, L. A. Cone, S. Shu, A. Morrow, B. Kowshik, and M. V. S. Andavolu, “Molecular interactions of leptin and prostate cancer,” Cancer Journal, vol. 12, no. 3, pp. 201–206, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. Z. Kote-Jarai, R. Singh, F. Durocher et al., “Association between leptin receptor gene polyrnorphisms and early-onset prostate cancer,” BJU International, vol. 92, no. 1, pp. 109–112, 2003. View at Publisher · View at Google Scholar · View at Scopus
  38. S. M. Pulukuri, C. S. Gondi, S. S. Lakka et al., “RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo,” Journal of Biological Chemistry, vol. 280, no. 43, pp. 36529–36540, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. S. Attoub, V. Noe, L. Pirola et al., “Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, Rho-, and Rac-dependent signaling pathways,” The FASEB Journal, vol. 14, no. 14, pp. 2329–2338, 2000. View at Google Scholar · View at Scopus
  40. S. Samuel-Mendelsohn, M. Inbar, E. Weiss-Messer, L. Niv-Spector, A. Gertler, and R. J. Barkey, “Leptin signaling and apoptotic effects in human prostate cancer cell lines,” Prostate, vol. 71, no. 9, pp. 929–945, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. R. Ribeiro, C. Lopes, and R. Medeiros, “The link between obesity and prostate cancer: the leptin pathway and therapeutic perspectives,” Prostate Cancer and Prostatic Diseases, vol. 9, no. 1, pp. 19–24, 2006. View at Publisher · View at Google Scholar · View at Scopus
  42. M. R. Hoda, H. El-Achkar, E. Schmitz, T. Scheffold, H. O. Vetter, and R. De Simone, “Systemic stress hormone response in patients undergoing open heart surgery with or without cardiopulmonary bypass,” Annals of Thoracic Surgery, vol. 82, no. 6, pp. 2179–2186, 2006. View at Publisher · View at Google Scholar · View at Scopus
  43. R. Ribeiro, C. Lopes, and R. Medeiros, “Leptin and prostate: implications for cancer prevention—overview of genetics and molecular interactions,” European Journal of Cancer Prevention, vol. 13, no. 5, pp. 359–368, 2004. View at Publisher · View at Google Scholar · View at Scopus
  44. M. Krasilnikov, V. N. Ivanov, J. Dong, and Z. Ronai, “ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications towards sensitization to apoptosis,” Oncogene, vol. 22, no. 26, pp. 4092–4101, 2003. View at Publisher · View at Google Scholar · View at Scopus