Journal of Oncology / 2012 / Article / Tab 1

Review Article

Targeting the Tumor Microenvironment: Focus on Angiogenesis

Table 1

Tumor microenvironment and its compartments.

Tumor entities
MicroenvironmentEpithelial solid tumorsHematological tumors
For example, Breast CancerFor example, multiple myeloma

Extracellular matrix (ECM)fibronectin, laminin, collagen, proteoglycans, thrombospondin, fibrinogen, elastin, fibrin, tenascin, tetranectinfibronectin, laminin, collagen, proteoglycans, glycosaminoglycans

CellularHematopoietic: TAM, T and B lymphocytes, neutrophils, NK cells, mesenchymal stem cellsHematopoietic: HSCs, BM-derived CEPs, hematopoietic and mesenchymal progenitor and precursor cells, NK cells, NKT cells, macrophages, T and B lymphocytes, DCs, monocytes, platelets, megakaryocytes, erythrocytes
nonhematopoietic: CAFS, myoepithelial cells, ECs, pericytesnonhematopoietic: fibroblasts/BMSCs, chondrocytes, OCs, OBs, ECs

LiquidHormones: estrogen, progesterone
cytokines and growth factors: VEGF, HGF/SF, bFGF, PDGFα/β, TGFα/β, IL-1, IL-6, TNFα, GM-CSF, CSF-1, IGF-1/2, EGF, SDF-1Cytokines and growth factors: VEGF, IGFs, TNFα, CD40, IL-1, IL-6, IL-10, IL-11, IL-15, IL-21, HGF, bFGF, SDF-1, TGFβ, LIF, OSM, MIP-1α, Wnts
proteases: cathepsin B and D, elastase, uPA, plasmin, MMPs (e.g., MMP-1, -2, -3, -9)proteases: uPA, plasmin, MMPs (e.g., MMP-2, -9)

TAM: tumor-associated macrophage; NK: nature killer; CAFS: cancer-associated fibroblasts; EC: endothelial cell; HSC: hematopoietic stem cells; CEP: circulating endothelial precursor; NKT: nature killer T; DC: dendritic cell; BMSC: bone marrow stromal cell; OC: osteoclast; OB: osteoblast; VEGF: vascular endothelial growth factor; HGF/SF: hepatocyte growth factor/scatter factor; bFGF: basic Fibroblast Growth Factors; PDGF: platelet-derived growth factor; TGF: transforming growth factor; TNF: tumor necrosis factor; IL: interleukin; GM-CSF: granulocyte macrophage colony stimulating factor; CSF: colony stimulating factor; EGF: epidermal growth factor; SDF: stromal cell-derived factor; uPA: urokinase plasminogen activator; MMP: matrix metalloproteinase; IGF: Insulin-like growth factor; LIF: leukaemia inhibitory factor; OSM: oncostatin M; MIP-1α: macrophage inflammatory protein 1α.
References for breast cancer: [811].
References for multiple myeloma: [12].

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