Review Article
Role of Protein Biomarkers in the Detection of High-Grade Disease in Cervical Cancer Screening Programs
Table 2
Biomarker positivity by histological grade of cervical intraepithelial lesion.
| | Study | Biomarker | WNL | CIN1 | CIN2+ |
| | Ki-67 | 2/14 (14%) | 29/34 (85%) | 14/14 (100%) | |
Shi 2007 et al.[62] | p16INK4a | 0/14 (0%) | 26/34 (77%) | 14/14 (100%) | | BD ProEx C | 0/14 (0%) | 32/34 (94%) | 11/14 (79%) | | BD ProEx C/p16 | 0/14 (0%) | 34/34 (100%) | 14/14 (100%) |
| | Ki-67 | 0/37 (0%) | 6/22 (27%) | 34/37 (91%) | |
Badr 2008 et al. [63] | p16INK4a | 2/38 (5%)* | 8/23 (35%)** | 35/37 (93%) | | BD ProEx C | 1/38 (3%) | 11/23 (48%) | 34/37 (92%) | | BD ProEx C/p16 | 3/35 (9%) | 15/23 (65%) | 37/37 (100%) |
| | Ki-67 | 11/23 (48%) | ND | 34/36 (94%) | |
Pinto 2008 et al. [64] | p16INK4a | 13/35 (37%) | ND | 51/61 (84%) | | BD ProEx C | 10/35 (29%) | ND | 52/60 (87%) | | BD ProEx C/p16 | 9/23 (39%) | ND | 33/36 (92%) |
| | Ki-67 | 14/29 (48%)a | 22/27 (82%) | 15/16 (94%) | |
Halloush 2008 et al. [65] | p16INK4a | 19/29 (66%)b | 25/27 (92%) | 19/19 (100%) | | BD ProEx C | 2/29 (7%)c | 2/27 (7%) | 16/19 (84%) |
| | Ki-67 | 6/26 (23%) | 10/21 (48%) | 76/85 (89%) | |
Conesa-Zamora 2009 et al. [66] | p16INK4a | 4/28 (14%) | 12/19 (63%) | 74/85 (87%) | | BD ProEx C | 3/25 (12%) | 10/19 (53%) | 70/80 (88%) |
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WNL: within normal limits; CIN: cervical intraepitelial neoplasia; ND: not determined; *Spotty staining;ā**5/23 spotty staining; a12/29 <1% staining, 2/29 ā„1% staining; b19/29 <10% staining; c1/29 <10%.
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