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Journal of Oncology
Volume 2012, Article ID 362096, 7 pages
http://dx.doi.org/10.1155/2012/362096
Research Article

The Characteristics of Vascular Growth in VX2 Tumor Measured by MRI and Micro-CT

Imaging Research, Sunnybrook HSC, University of Toronto, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5

Received 1 June 2011; Revised 14 July 2011; Accepted 15 July 2011

Academic Editor: Arkadiusz Dudek

Copyright © 2012 X.-L. Qi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Blood supply is crucial for rapid growth of a malignant tumor; medical imaging can play an important role in evaluating the vascular characterstics of tumors. Magnetic resonance imaging (MRI) and micro-computed tomography (CT) are able to detect tumors and measure blood volumes of microcirculation in tissue. In this study, we used MR imaging and micro-CT to assess the microcirculation in a VX2 tumor model in rabbits. MRI characterization was performed using the intravascular contrast agent Clariscan (NC100150-Injection); micro-CT with Microfil was used to directly depict blood vessels with diameters as low as 17 um in tissue. Relative blood volume fraction (rBVF) in the tumor rim and blood vessel density (rBVD) over the whole tumor was calculated using the two imaging methods. Our study indicates that rBVF is negatively related to the volume of the tumor measured by ultrasound ( 𝑅 = 0 . 9 0 ). rBVF in the tissue of a VX2 tumor measured by MRI in vivo was qualitatively consistent with the rBVD demonstrated by micro-CT in vitro ( 𝑅 = 0 . 9 7 ). The good correlation between the two methods indicates that MRI studies are potentially valuable for assessing characteristics or tumor vascularity and for assessing response to therapy noninvasively.