Definitive Radiotherapy versus Postoperative Radiotherapy of Patients with Oro- and Hypopharyngeal Cancer: Impact of Prognostic Factors

Table 2

Definitive radiation therapy: univariate analysis of overall survival, locoregional control, and metastasis-free survival.

Factor	Overall survival		Locoregional failure		Metastasis
	5y-survival	𝑃	5y-CIF	𝑃	5y-CIF	𝑃
Gender
Female	0.15 (95% CI 0.01–0.45)		0.60 (95% CI 0.50–0.68)		0.22 (95%0 CI 0.04–0.49)
Male	0.28 (95% CI 0.19–0.37)	0.39	0.61 (95% CI 0.52–0.70)	0.52	0.33 (95% CI 0.24–0.42)	0.47
Age (years)
≤56	0.27 (95% CI 0.17–0.39)		0.63 (95% CI 0.51–0.73)		0.34 (95% CI 0.23–0.45)
>56	0.25 (95% CI 0.13–0.40)	0.43	0.63 (95% CI 0.46–0.76)	0.29	0.28 (95% CI 0.17–0.40)	0.61
Hemoglobin level pre-RT (g/dL)
≤12	0.09 (95% CI 0.01–0.30)		0.82 (95% CI 0.56–0.93)		0.25 (95% CI 0.07–0.48)
>12	0.30 (95% CI 0.20–0.40)	0.02	0.58 (95% CI 0.47–0.67)	0.01	0.33 (95% CI 0.23–0.42)	0.46
Tumor site
Oropharynx	0.24 (95% CI 0.14–0.35)		0.69 (95% CI 0.56–0.78)		0.34 (95% CI 0.24–0.44)
Hypopharynx	0.30 (95% CI 0.17–0.44)	0.70	0.54 (95% CI 0.39–0.67)	0.14	0.28 (95% CI 0.16–0.42)	0.32
T-Classification
1, 2	0.44 (95% CI 0.13–0.72)		0.41 (95% CI 0.13–0.67)		0.25 (95% CI 0.05–0.51)
3, 4	0.25 (95% CI 0.17–0.34)	0.34	0.65 (95% CI 0.55–0.73)	0.28	0.33 (95% CI 0.24–0.42)	0.70
N-Classification
0, 1	0.52 (95% CI 0.19–0.77)		0.17 (95% CI 0.02–0.43)		0.16 (95% CI 0.02–0.41)
2, 3	0.26 (95% CI 0.17–0.34)	0.17	0.66 (95% CI 0.56–0.74)	<0.01	0.33 (95% CI 0.24–0.41)	0.38
Total tumor volume (cm^3)
≤68.4	0.36 (95% CI 0.22–0.51)		0.46 (95% CI 0.33–0.59)		0.29 (95% CI 0.15–0.44)
>68.4	0.18 (95% CI 0.09–0.30)	<0.01	0.78 (95% CI 0.62–0.88)	<0.01	0.37 (95% CI 0.24–0.50)	0.13
Simultaneous radiochemotherapy
Yes	0.32 (95% CI 0.21–0.42)		0.57 (95% CI 0.46–0.67)		0.37 (95% CI 0.27–0.48)
No	0.17 (95% CI 0.05–0.37)	0.03	0.73 (95% CI 0.53–0.85)	0.08	0.21 (95% CI 0.1–0.34)	0.04
RT interruptions >5 days
Yes	0.15 (95% CI 0.01–0.43)		0.58 (95% CI 0.29–0.78)		0.28 (95% CI 0.13–0.44)
No	0.28 (95% CI 0.19–0.38)	0.51	0.64 (95% CI 0.53–0.73)	0.83	0.33 (95% CI 0.23–0.42)	0.96

RT, radiation therapy; CIF, cumulative incidence function; 𝑃: 𝑃 value.