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Journal of Oncology
Volume 2012 (2012), Article ID 507286, 9 pages
http://dx.doi.org/10.1155/2012/507286
Review Article

Biomarkers of Cervical Dysplasia and Carcinoma

1Department of Pathology, Hospital Level 2, Room 766, Stony Brook University Medical Center, Stony Brook, NY 11794-7025, USA
2Department of Pathology, Basic Science Tower, Level 9, Stony Brook University Medical Center, Stony Brook, NY 11794-8691, USA

Received 2 August 2011; Accepted 8 September 2011

Academic Editor: Adhemar Longatto-Filho

Copyright © 2012 Sonya J. Hwang and Kenneth R. Shroyer. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Although cervical cytology screening has decreased the incidence of cervical cancer in industrialized countries, HPV-related cervical disease, including premalignant and malignant lesions, continues to represent a major burden on the health care system. Some of the problems include the potential for either under- or overtreatment of women due to decreased specificity of screening tests as well as significant interobserver variability in the diagnosis of cervical dysplastic lesions. Although not completely elucidated, the HPV-driven molecular mechanisms underlying the development of cervical lesions have provided a number of potential biomarkers for both diagnostic and prognostic use in the clinical management of these women.