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Journal of Oncology
Volume 2012, Article ID 512976, 10 pages
Clinical Study

N-Acetyltransferase 1 (NAT1) Genotype: A Risk Factor for Urinary Bladder Cancer in a Lebanese Population

1Faculty of Health Sciences, University of Balamand, Beirut 1100-2807, Lebanon
2School of Public Health, University of California-Los Angeles (UCLA), Los Angeles, CA 90095, USA
3Urology Department, St. George Hospital University Medical Center, Faculty of Medicine, University of Balamand, Beirut 1100-2807, Lebanon
4Medical Laboratory Sciences, Faculty of Health Sciences, University of Balamand, P.O. Box 166378 Ashrafieh, Beirut 1100-2807, Lebanon

Received 8 March 2012; Revised 14 May 2012; Accepted 27 May 2012

Academic Editor: Anirban P. Mitra

Copyright © 2012 Ibrahim A. Yassine et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In Lebanon, bladder cancer is the second most incident cancer among men. This study investigates a possible association between N-acetyltransferase 1 (NAT1) genotype, a drug-metabolizing enzyme coding gene, and bladder cancer in Lebanese men. A case-control study (54 cases and 105 hospital-based controls) was conducted in two major hospitals in Beirut. Cases were randomly selected from patients diagnosed in the period of 2002–2008. Controls were conveniently identified and selected from the same settings. Data was collected using interview questionnaire and blood analysis. NAT1 genotypes were determined by PCR-RFLP. Statistical analysis revolved around univariate, bivariate, and multivariate logistic regression models, along with checks for effect modification. Results showed NAT114A allele, smoking, occupational exposure to combustion fumes, and prostate-related symptoms, to be risk factors for bladder cancer. The odds of carrying at least one NAT114A allele are 7 times higher in cases compared to controls (OR=7.86, 95% CI: 1.53–40.39). A gene-environment interaction was identified for NAT114A allele with occupational exposure to combustion fumes. Among carriers of NAT114A allele, the odds of bladder cancer dropped to 2.03 from 3.72. Our study suggests NAT114A allele as a possible biomarker for bladder cancer. Further research is recommended to confirm this association.