Review Article

Utility of Vascular Endothelial Growth Factor Inhibitors in the Treatment of Ovarian Cancer: From Concept to Application

Table 4

Ongoing clinical trials of bevacizumab combined with chemotherapy in ovarian cancer.

Trial numberPhaseChemotherapyStage of the diseaseNumber of patients (estimated)

NCT00127920 (AV53206s)IICarboplatin + paclitaxel + bevacizumabNewly diagnosed stage III/IV20
NCT00296816 (TEACO)IIOxaliplatin + docetaxel + bevacizumabNewly diagnosed stage IB-IV145
NCT00511992 (AVF3953)IIPaclitaxel + cisplatin + bevacizumab followed by bevacizumabNewly diagnosed stage II-III20
NCT00588237 (06-064)IIPaclitaxel + cisplatin + bevacizumabInitial treatment of optimal stage II or III (adjuvant)42
NCT00267696 (2005CO073)IIGemcitabine + carboplatin + bevacizumabPlatinum-sensitive recurrent45
NCT00698451 (CR015094)IICarboplatin + liposomal doxorubicin + bevacizumabPlatinum-sensitive recurrent54
NCT00418093 (04-356)IIOxaliplatin + gemcitabine + bevacizumabPlatinum-sensitive recurrent40
NCT00868192 (08-0508)IIPemetrexed + bevacizumabRecurrent having failed platinum- and taxane-based regimens25
NCT00504257 (MCC-14920, MCC-105366c)IIDocetaxel + bevacizumabPlatinum-resistant recurrent44
NCT00744718 (2008-000878-20, S-20080033)IICarboplatin + bevacizumabPlatinum-resistant recurrent30
NCT00846612 (06-948, AVF3910s)IILiposomal doxorubicin + bevacizumabPlatinum-resistant recurrent48
NCT00856180 (08-148)IICyclophosphamide + bevacizumabPlatinum-resistant recurrent20
NCT00407563 (ALSSOPR0501)IIAbraxane (protein-bound paclitaxel ) + bevacizumabPlatinum-resistant recurrent48
NCT00937560 (MO22225)IICarboplatin + paclitaxel + bevacizumabPreviously untreated, but initial surgery188
NCT00583622 (2007-0368)IIGemcitabine + docetaxel + melphalan + carboplatin + bevacizumabSecond or later complete remission, or untreated or refractory relapse to platinum treatment or lack of response to salvage treatment40
NCT00483782 (ICON7)IIICarboplatin + paclitaxel ± bevacizumabNewly diagnosed1520
NCT00262847 (GOG218)IIICarboplatin + paclitaxel versus carboplatin + paclitaxel + bevacizumab ± maintenance bevacizumabNewly diagnosed, previously untreated stage III or IV2000
NCT00565851 (GOG213)IIICarboplatin + paclitaxel ± bevacizumab followed by bevacizumab and secondary cytoreduction surgeryPlatinum-sensitive recurrent660
NCT00434642 (OCEANS, AVF4095g)IIICarboplatin + gemcitabine ± bevacizumabPlatinum-sensitive recurrent487
NCT00652119 (2007-0223)N/ACarboplatin + paclitaxel + bevacizumabNewly diagnosed stage III/IV46

*Accessed from http://www.clinicaltrials.gov/ on April 18, 2011.