Review Article

WAVE2 Protein Complex Coupled to Membrane and Microtubules

Figure 1

PI3K-dependent dissociation of IQGAP1 and kinesin-1 from the Rac1-CLIP-170 complex and successive binding of them to WAVE2 after GF stimulation. (a) IQGAP1 and kinesin-1, which are bound to Rac1 via CLIP-170 in growth-arrested cells, dissociate from the Rac1-CLIP-170 complex after GF stimulation in a PI3K-dependent manner. (b) Dissociated IQGAP1 and kinesin-1 bind to the WAVE2 complex, which consists of IQGAP1 and kinesin-1. GF: growth factor; GF-R: growth factor receptor; PI3K: phosphoinositide 3-kinase; CLIP-170: cytoplasmic linker protein 170; IQGAP1: IQ motif-containing guanine nucleotide activating protein 1; WAVE2: Wiskott-Aldrich protein verprolin homology protein 2; F-actin: actin filaments.
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(a)
590531.fig.001b
(b)