WAVE2 Protein Complex Coupled to Membrane and Microtubules
Figure 2
Activation of WAVE2-bound Pak1, phosphorylation of stathmin by Pak1, and recruitment of the phosphorylated stathmin-EB1 complex to the microtubule ends that bear the WAVE2 complex. (a) WAVE2-bound Pak1 is activated and in turn phosphorylates stathmin that complexes with EB1. (b) The phosphorylated stathmin-EB1 complex is recruited to microtubule ends that bear the WAVE2 complex through kinesin-1. Pak1: p21-activated protein kinase 1; EB1: microtubule end-binding protein 1.
