Review Article

WAVE2 Protein Complex Coupled to Membrane and Microtubules

Figure 4

The role of nonmuscle myosin IIA in lamellipodia formation. The network of F-actin, initially rearranged by WAVE2, IRSp53, and PIP3, is assembled into lamellipodium, a convex arc of F-actin, by the WAVE2-bound nonmuscle myosin IIA heavy chain MYH9 and the motor activity of nonmuscle myosin II.
590531.fig.004