Metastatic Behavior in Melanoma: Timing, Pattern, Survival, and Influencing Factors

Table 1

Patient’s characteristics.

Parameter	Metastasis at presentation (%)	Metastasis during follow-up (%)
	31	69
Gender
Male	65	61
Female	35	39
Age
Median (range)	50 (22–86)	49 (24–83)
Localization
Axial	56	58
Extremity	44	42
Histology
Nodular	50	51
Nonnodular	50	49
Breslow thickness
<4mm	50	51
>4mm	50	49
Clark invasion
I–III	5	18
IV-V	95	82
Ulceration
No	36	17
Yes	64	83
Mitotic rate (/mm^2)
Median (range)	3 (1–46)	4 (1–52)
Lymphocyte infiltration
No	47	40
Yes	53	60
Regression
No	83	85
Yes	17	15
Vascular invasion
No	71	82
Yes	29	18
Neurotropism
No	89	93
Yes	11	7