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Journal of Oncology
Volume 2012 (2012), Article ID 709049, 15 pages
http://dx.doi.org/10.1155/2012/709049
Review Article

Early Detection Biomarkers for Ovarian Cancer

1The Genomics and Biomarker Program, The John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ 07601, USA
2Genewiz, Inc., South Plainfield, NJ 07080, USA
3The John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ 07601, USA

Received 19 June 2012; Accepted 19 November 2012

Academic Editor: William J. Hoskins

Copyright © 2012 Sreeja Sarojini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Despite the widespread use of conventional and contemporary methods to detect ovarian cancer development, ovarian cancer remains a common and commonly fatal gynecological malignancy. The identification and validation of early detection biomarkers highly specific to ovarian cancer, which would permit development of minimally invasive screening methods for detecting early onset of the disease, are urgently needed. Current practices for early detection of ovarian cancer include transvaginal ultrasonography, biomarker analysis, or a combination of both. In this paper we review recent research on novel and robust biomarkers for early detection of ovarian cancer and provide specific details on their contributions to tumorigenesis. Promising biomarkers for early detection of ovarian cancer include KLK6/7, GSTT1, PRSS8, FOLR1, ALDH1, and miRNAs.