Review Article
Early Detection Biomarkers for Ovarian Cancer
Figure 1
EGF/EGFR-based signaling pathways of ovarian cancer biomarkers. (a) Non-EGF/EGFR-based signaling pathways. (b) indicates upregulation. indicates downregulation. Caveolin-1 (Cav-1); phosphoinositide-3-kinase (PI3K); c-Jun N-terminal kinase (JNK); extracellular signal-regulated kinase (ERK); homeodomain-interacting protein kinase-2 (HIPK2); matrix metalloproteinase-2 or 7 (MMP-2 or MMP-7); multidrug-resistant protein (MDR1, P-glycoprotein); multidrug resistance-associated proteins 1 and 2 (MRP1/2); mitogen-activated protein kinase (MAP-K); phosphatase and tensin homolog (PTEN).
