|
| Gene | Cancer/metastatic tumor | Function(s) of protein | OMIM no. | Chromosome location |
|
| ERBB2 (HER2) | Breast | Receptor tyrosine kinase, critical component of IL6, and cytokine signaling | 164870 | 17q21.1 |
|
| TIAM1 | Lymphomas, renal cell cancer, colon, prostate, and breast | Activates Rho-like GTPase Rac1, Tiam1Rac1 signaling which affects invasion in numerous ways | 600687 | 21q22.1 |
|
| SRC | Colorectal, breast, melanoma, and lung | Critical role in cellular signal transduction pathways, regulating cell division, motility, adhesion, angiogenesis, and survival | 190090 | 20q12-q13 |
|
| S100A4 | Colorectal
Breast
Gastric cancers | Increases endothelial cell motility and induces angiogenesis, increases invasive properties through deregulation of the extracellular matrix | 114210 | 1q21 |
|
| MTA1 | Breast
Ovary
Lung
Gastrointestinal
Colorectal | Nucleosome remodeling and deacetylating (NuRD) complex serves multiple functions in cellular signaling, chromosome remodeling and transcription processes, that are important in the progression, invasion, and growth of metastatic epithelial cells | 603526 | 14q32.3 |
|
| KRAS | Pancreatic
Lung
Colorectal | Encode GDP/GTP-binding proteins involved in signal transduction during cellular proliferation, differentiation, and senescence | 190070 | 12p12.1 |
|
| HRAS | Bladder
Renal
Thyroid | Small GTPase growth promoting factor | 190020 | 11p15.5 |
|
