Merkel Cell Carcinoma: A Retrospective Study on 48 Cases and Review of Literature

Table 1

Merkel cell carcinoma series (1990–2012).

Sex	Age	Site	Type	Size (cm)	Stage	Ki67% (MIB1)	ChrA staining	NSE staining	ChrA (ng/mL)	NSE (ng/mL)	Therapy	Survival (months)	Other
F	83	EXTR	NOD/ULC	3	III	—	NEG	POS	—	—	SURG + SMS	36	RA
M	52	EXTR	NOD	—	—	—	—	—	—	—	SURG + RT	2
F	76	BUTTOCK	NOD	3	II	—	NEG	NEG	—	—	SURG	—
F	75	EXTR	NOD	1	I	30	POS	POS	—	—	SURG + RT	29	RA
M	70	NS	—	3	III	>50	NEG	POS	—	—	SURG + SMS	8	HCV+
F	81	NS	—	1.5	III	—	—	—	—	—	SURG + RT + SMS	26
F	83	HEAD	NOD	1.2	I	—	NEG	POS	177	5.4	SURG + RT	24
M	55	BUTTOCK	NOD	3.5	IV	—	—	—	52.2	39.8	SURG + CHT	25
M	80	TRUNK	NOD	2.2	II	>70	POS	POS	43.2	5.5	SURG + SMS	24
F	74	HEAD	NOD/CYS	—	I	—	—	—	—	6.3	SURG + RT + SMS + α IFN	15
M	70	EXTR	NOD	0.8	I	—	—	—	—	—	SURG	—	HCV+
F	72	HEAD	NOD	1	I	80	—	—	—	—	SURG	—	Ca breast, Ca lung
F	63	NS	—	5	III	—	—	POS	51	31.3	SURG	25	HCV+ Ca uterus
M	74	EXTR	NOD	1.5	I	—	POS	—	136	5.4	SURG	3
M	70	NS	—	—	IV	—	—	—	—	—	SURG + CHT	12
M	85	EXTR	NOD	8	III	25	POS	—	870	43	SURG + SMS	37	Kaposi sarcoma
F	61	EXTR	NOD	4.3	II	80	POS	POS	—	—	SURG	—
M	76	HEAD	NOD	1.5	III	—	POS	POS	185	8.3	SURG	—	Ca rectus
F	84	EXTR	NOD	2.0	IV	—	POS	POS	—	—	SURG + CHT	48
F	79	EXTR	NOD	1.5	I	—	—	—	—	—	SURG + RT	—
M	76	EXTR	NOD	—	IV	—	—	—	—	—	SURG + CHT	12
F	72	NS	—	4.5	IV	80	POS	—	70	81.2	SURG + CHT + SMS	58
M	55	EXTR	NOD	1	III	—	NEG	—	—	—	SURG	—
F	80	EXTR	NOD/ULC	1.7	I	80	POS	POS	—	—	SURG	—
M	67	HEAD	NOD	0.5	I	—	—	—	—	—	SURG	—
M	70	NS	—	—	IV	70	—	—	46	13	SURG + CHT	16
M	70	EXTR	NOD	2	IV	40	—	—	99.3	17.8	SURG + RT + CHT + SMS	27
F	61	NS	—	6	IV	50	—	—	50	21.3	SURG + CHT	—
M	63	BUTTOCK	NOD	5	IV	50	POS	—	—	—	SURG	15	LNH
M	95	HEAD	NOD	1.2	I	70	POS	—	—	—	SURG	—
M	80	HEAD	NOD	0.5	IV	—	—	—	46	8.9	SURG + RT + CHT + SMS + RMT	17
M	74	NS	—	—	IV	—	—	NEG	—	—	SURG + RT + CHT + SMS	23
F	69	EXTR	NOD	—	IV	—	—	—	—	—	SURG	—
M	64	NS	—	3	II	60	—	POS	156	8.0	SURG	—
F	60	HEAD	NOD	0.7	I	90	POS	POS	—	—	SURG	—
M	89	BUTTOCK	NOD	—	IV	80	POS	—	760	86.2	SURG + RT + CHT	13
F	65	EXTR	NOD	—	—	—	—	—	—	—	SURG	—
M	59	EXTR	NOD	1	III	—	POS	POS	—	—	SURG	6
M	64	HEAD	NOD	1.1	III	60	POS	—	—	—	SURG	—	RA
F	59	EXTR	NOD	0.6	I	22	—	—	—	—	SURG	17
M	75	NS	—	4	IV	—	—	—	—	—	SURG	6	HCV+
F	59	NS	—	1	I	40	POS	—	—	—	SURG	14
F	78	EXTR	NOD	2.5	III	—	—	—	—	—	SURG	—
F	60	NS	—	—	IV	—	—	—	—	—	SURG	—	Paraneoplastic polineuritis
M	69	EXTR	NOD	2	III	35	POS	POS	116	10	SURG + RT	5	Transpl
F	74	NS	—	6	IV	—	POS	—	700	102	SURG + CHT+ SMS	52
M	58	NS	—	2.5	III	80	POS	POS	46.5	5.3	SURG + RT	—
M	63	NS	—	1.2	IV	80	POS	—	1500	17.20	SURG + CHT + SMS	22

AR: rheumatoid arthritis, ChrA: chromogranin A, 19–98 ng/mL, CHT: chemotherapy, EXTR: extremities, F: female, α IFN: alpha interferon, M: male, NS: no skin (unknown primary site), NSE: neuron-specific enolase, <12 ng/mL, RM: receptor radionuclide therapy, RT: radiotherapy, SMS: somatostatin analogues, SURG: Surgery, TRANS: transplanted.