Targeting Angiogenesis for Controlling Neuroblastoma
Genomic and non-genomic actions of all-trans retinoic acid (ATRA). Genomic action of ATRA includes caspase-8 transcription, cell cycle arrest, and apoptosis. Non-genomic action of ATRA involves induction of PI3K/Akt pathway for upregulation of secretase. ATRA activates retinoic acid receptor (RAR) and MAPK signaling pathway for contribution to differentiation in neuroblastoma.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.