Journal of Oncology / 2012 / Article / Fig 3

Research Article

Lack of Efficacy of Combined Antiangiogenic Therapies in Xenografted Human Melanoma

Figure 3

Dual immunofluorescence staining for CD31 and Tie2. (a) Tie2 was fluorescently labeled red using Cy3 while CD31 was fluorescently labeled green using FITC. Representative Tie2-positive blood vessels are marked with an asterisk while representative Tie2-negative blood vessels are labeled with arrows. (b) Quantification of average blood vessel densities (as number of CD31-positive vessels/mm2) between treatment groups. There were no statistically significant differences in blood vessel density between different treatment groups ( 𝑃 > 0 . 0 5 ). (c) Quantification of % Tie2-negative blood vessels in tumor xenografts treated with TekdeltaFc and/or LDM CTX. Graph depicts the average % of Tie2-negative blood vessels per treatment group; the difference between groups is not statistically significant ( 𝑃 > 0 . 0 5 ).

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