Journal of Oncology / 2012 / Article / Fig 5

Research Article

Lack of Efficacy of Combined Antiangiogenic Therapies in Xenografted Human Melanoma

Figure 5

Expression of VEGF in tumor xenografts. Concentration of VEGF levels in tumor lysates measured by ELISA and expressed as pg/mL normalized to protein content in the tumor lysate. (a) There were significant differences in human VEGF levels between treatment groups (* 𝑃 < 0 . 0 5 ). The lowest human VEGF concentration was detected in control tumors while the highest VEGF concentration was detected in combined treatment group, showing that TekdeltaFc and LDM CTX therapy both individually and in combination significantly upregulated melanoma cell VEGF expression. (b) There were no significant differences in murine VEGF between treatment groups ( 𝑃 > 0 . 0 5 ).

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