Dual Roles of METCAM in the Progression of Different Cancers
HuMETCAM protein structure. SP stands for signal peptide sequence: V1, V2, C2, C2′, and C2′′ for five Ig-like domains (each held by a disulfide bond) and X for one domain (without any disulfide bond) in the extracellular region, and TM for transmembrane domain. P stands for five potential phosphorylation sites (one for PKA, three for PKC, and one for CK2) in the cytoplasmic tail. The six conserved N-glycosylation sites are shown as wiggled lines in the extracellular domains of V1, the region between C2′ and C2′′, C2′′, and X.
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