Dual Roles of METCAM in the Progression of Different Cancers

Figure 14

Enforced expression of moMETCAM suppressed lung nodule formation of mouse melanoma K9 cells in syngeneic C3H mice. Clones METCAM (high)-K9 and METCAM (low)-K9 clones expressed high and low levels of moMETCAM, respectively. Vector-K9, K9 parental cells, and Rev-K9, in which the moMETCAM cDNA was inserted into the expression vector in antisense orientation, were the control clones that did not express any moMETCAM.