Journal of Oncology / 2012 / Article / Tab 1

Review Article

Dual Roles of METCAM in the Progression of Different Cancers

Table 1

The role of METCAM in the tumorigenesis and metastasis of various cancer cells.

Cancer cellsTumorigenesisMetastasisReferences

Clinical prostate cancer and human prostate cancer cell linesIncreasingIncreasing (effect is in the early stage of initiation)[7, 8, 12, 13, 35, 36]
Mouse prostate carcinomas in TRAMP miceIncreasingIncreasing[41]
Clinical melanoma and human melanoma cell linesNo effectIncreasing (effect is in the late stages)[3, 20]
Mouse melanoma cell line of K1735 subline number 3 and 10sNo effect or slight suppressionIncreasing (effect is in the late stages)[9, 21]
Mouse melanoma cell line K1735 subline number 9SuppressionSuppression[22, 23] and Wu et al. unpublished results
AngiosarcomaIncreasingNot determined[7, 37] and Wu et al. unpublished results
Human ovarian cancer cell lines BG-1 and SK-OV-3Suppressionsuppression[33, 34]
Human osteosarcoma cell linesNot determinedIncreasing[39]
Human breast cancer cell line MCF-7SuppressionNot determined[24]
Human breast cancer cell lines MCF-7 and SK-BR-3IncreasingNot determined[30, 31]
HaemangiomasSuppression?Not determined[38]
Nasopharyngeal carcinomaSuppression?Not determined[7, 11]

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