Review Article
Dual Roles of METCAM in the Progression of Different Cancers
Table 1
The role of METCAM in the tumorigenesis and metastasis of various cancer cells.
| Cancer cells | Tumorigenesis | Metastasis | References |
| Clinical prostate cancer and human prostate cancer cell lines | Increasing | Increasing (effect is in the early stage of initiation) | [7, 8, 12, 13, 35, 36] | Mouse prostate carcinomas in TRAMP mice | Increasing | Increasing | [41] | Clinical melanoma and human melanoma cell lines | No effect | Increasing (effect is in the late stages) | [3, 20] | Mouse melanoma cell line of K1735 subline number 3 and 10s | No effect or slight suppression | Increasing (effect is in the late stages) | [9, 21] | Mouse melanoma cell line K1735 subline number 9 | Suppression | Suppression | [22, 23] and Wu et al. unpublished results | Angiosarcoma | Increasing | Not determined | [7, 37] and Wu et al. unpublished results | Human ovarian cancer cell lines BG-1 and SK-OV-3 | Suppression | suppression | [33, 34] | Human osteosarcoma cell lines | Not determined | Increasing | [39] | Human breast cancer cell line MCF-7 | Suppression | Not determined | [24] | Human breast cancer cell lines MCF-7 and SK-BR-3 | Increasing | Not determined | [30, 31] | Haemangiomas | Suppression? | Not determined | [38] | Nasopharyngeal carcinoma | Suppression? | Not determined | [7, 11] |
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