Human Papillomavirus Genotyping and E6/E7 mRNA Expression in Greek Women with Intraepithelial Neoplasia and Squamous Cell Carcinoma of the Vagina and Vulva

Table 3

Prevalence of HPV in intraepithelial neoplasia and carcinoma of the vagina, by study.

Histologic type	First; author	No. of; cases	HPV test	HPV prevalence for any; and specific genotypes
VAIN I
	Smith (review)	66	PCR/hybrid capture assays	Any HPV, 98.5%; Most common types; 16 (17.9%), 18 (17.9%)
	De Vuyst (meta-analysis)	107	PGMY reverse line blot/SPF 10 line probe assay, blot hybridization	Any HPV, 100%; Most common types; 16 (23.4%), 56 (11.0%), 51 (8.8%)
VAIN II/III
	Smith	166	PCR/hybrid capture assays	Any HPV, 92.6%; Most common type; 16 (65.8%)
	De Vuyst	191	PGMY reverse line blot/SPF 10 line probe assay, blot/southern hybridization, restriction fragment analysis, sequencing	Any HPV, 90.1%; Most common types; 16 (57.6%), 18 (6.9%), 58 (5.9%)
Vaginal SCC
	Smith	83	PCR/hybrid capture assays	Any HPV, 65.5%; Most common type; 16 (55.4%)
	De Vuyst	136	Reverse line blot assay, INNO-LiPA HPV genotyping, southern hybridization, restriction fragment analysis, sequencing	Any HPV, 69.9%; Most common types; 16 (53.7%), 18 (7.6%), 31 (5.6%)