Table of Contents Author Guidelines Submit a Manuscript
Journal of Oncology
Volume 2013, Article ID 872957, 9 pages
http://dx.doi.org/10.1155/2013/872957
Research Article

Enhancement of Cisplatin-Mediated Apoptosis in Ovarian Cancer Cells through Potentiating G2/M Arrest and p21 Upregulation by Combinatorial Epigallocatechin Gallate and Sulforaphane

1Department of Biology, University of Alabama at Birmingham, CH175, 1300 University Boulevard, Birmingham, AL 35294-1170, USA
2Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
3Center for Aging, University of Alabama at Birmingham, Birmingham, AL 35294, USA
4Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
5Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
6Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA

Received 19 December 2012; Accepted 10 January 2013

Academic Editor: Jorg Kleeff

Copyright © 2013 Huaping Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [39 citations]

The following is the list of published articles that have cited the current article.

  • Tiehong Zhang, Long Meng, Wei Dong, Hongchang Shen, Shuming Zhang, Qi Liu, and Jiajun Du, “High expression of PRDM14 correlates with cell differentiation and is a novel prognostic marker in resected non-small cell lung cancer,” Medical Oncology, vol. 30, no. 3, 2013. View at Publisher · View at Google Scholar
  • Joshua D. Lambert, “Does tea prevent cancer? Evidence from laboratory and human intervention studies,” American Journal of Clinical Nutrition, vol. 98, no. 6, pp. 1667S–1675S, 2013. View at Publisher · View at Google Scholar
  • Samriddhi Shukla, Syed M. Meeran, and Santosh K. Katiyar, “Epigenetic regulation by selected dietary phytochemicals in cancer chemoprevention,” Cancer Letters, 2014. View at Publisher · View at Google Scholar
  • Tiffany J. Tzeng, Lei Cao, YangXin Fu, Huawei Zeng, and Wen-Hsing Cheng, “Methylseleninic Acid Sensitizes Notch3-Activated OVCA429 Ovarian Cancer Cells to Carboplatin,” Plos One, vol. 9, no. 7, 2014. View at Publisher · View at Google Scholar
  • Yiran Zhang, Kaimin Hu, Yongxian Hu, Lizhen Liu, Binsheng Wang, and He Huang, “Bone marrow mesenchymal stromal cells affect the cell cycle arrest effect of genotoxic agents on acute lymphocytic leukemia cells via p21 down-regulation,” Annals of Hematology, 2014. View at Publisher · View at Google Scholar
  • Yu-Chao Ma, Cui Li, Feng Gao, Yan Xu, Zhi-Bin Jiang, Jian-Xin Liu, and Long-Yu Jin, “Epigallocatechin gallate inhibits the growth of human lung cancer by directly targeting the EGFR signaling pathway,” Oncology Reports, vol. 31, no. 3, pp. 1343–1349, 2014. View at Publisher · View at Google Scholar
  • Chunyang Jiang, Xiaoli Hu, Mohamed Alattar, and Hui Zhao, “miRNA expression profiles associated with diagnosis and prognosis in lung cancer,” Expert Review of Anticancer Therapy, pp. 1–9, 2014. View at Publisher · View at Google Scholar
  • Jee-Youn Kim, Inho Jo, Ji-Young Choi, Hyeon-Ju Lee, Catherine Jeonghae Byun, Jung-Hyun Park, Jae Hoon Park, Ho-Seong Cho, Sung-Jin Cho, and Sangmee Ahn Jo, “The green tea component (-)-epigallocatechin-3-gallate sensitizes primary endothelial cells to Arsenite-induced apoptosis by decreasing C-Jun n-Terminal Kinase-mediated Catalase activity,” PLoS ONE, vol. 10, no. 9, 2015. View at Publisher · View at Google Scholar
  • Michal Pastorek, Veronika Simko, Martina Takacova, Monika Barathova, Maria Bartosova, Luba Hunakova, Olga Sedlakova, Sona Hudecova, Olga Krizanova, Franck Dequiedt, Silvia Pastorekova, and Jan Sedlak, “Sulforaphane reduces molecular response to hypoxia in ovarian tumor cells independently of their resistance to chemotherapy,” International Journal Of Oncology, vol. 47, no. 1, pp. 51–60, 2015. View at Publisher · View at Google Scholar
  • Christian Mayr, Andrej Wagner, Daniel Neureiter, Martin Pichler, Martin Jakab, Romana Illig, Frieder Berr, and Tobias Kiesslich, “The green tea catechin epigallocatechin gallate induces cell cycle arrest and shows potential synergism with cisplatin in biliary tract cancer cells,” BMC Complementary and Alternative Medicine, vol. 15, no. 1, 2015. View at Publisher · View at Google Scholar
  • Rosanna H. E. Krakowsky, and Trygve O. Tollefsbol, “Impact of Nutrition on Non-Coding RNA Epigenetics in Breast and Gynecological Cancer,” Frontiers in Nutrition, vol. 2, 2015. View at Publisher · View at Google Scholar
  • Maria Teresa Piccolo, Stefania Crispi, and Ciro Menale, “Combined anticancer therapies: An overview of the latest applications,” Anti-Cancer Agents in Medicinal Chemistry, vol. 15, no. 4, pp. 408–422, 2015. View at Publisher · View at Google Scholar
  • Xuemin Wang, Pan Jiang, Pengqi Wang, Chung S. Yang, Xuerong Wang, and Qing Feng, “EGCG enhances Cisplatin sensitivity by regulating expression of the copper and cisplatin influx transporter CTR1 in ovary cancer,” PLoS ONE, vol. 10, no. 4, 2015. View at Publisher · View at Google Scholar
  • Biao Wang, Shuo Li, Xin Meng, Hong Shang, and Yifu Guan, “Inhibition of mdr1 by G-quadruplex oligonucleotides and reversal of paclitaxel resistance in human ovarian cancer cells,” Tumor Biology, 2015. View at Publisher · View at Google Scholar
  • Sonam Sinha, Samriddhi Shukla, Sajid Khan, Trygve O. Tollefsbol, and Syed M. Meeran, “Epigenetic reactivation of p21CIP1/WAF1 and KLOTHO by a combination of bioactive dietary supplements is partially ERα-dependent in ERα-negative human breast cancer cells,” Molecular and Cellular Endocrinology, 2015. View at Publisher · View at Google Scholar
  • Yan Wang, Yuanyuan Liu, Yang Liu, Wen Zhou, Hemei Wang, Guoyun Wan, Duxin Sun, Ning Zhang, and Yinsong Wang, “A polymeric prodrug of cisplatin based on pullulan for the targeted therapy against hepatocellular carcinoma,” International Journal of Pharmaceutics, 2015. View at Publisher · View at Google Scholar
  • Kendra J. Royston, and Trygve O. Tollefsbol, “The Epigenetic Impact of Cruciferous Vegetables on Cancer Prevention,” Current Pharmacology Reports, 2015. View at Publisher · View at Google Scholar
  • Arshad H. Rahmani, Fahad M. Al shabrmi, Khaled S. Allemailem, Salah M. Aly, and Masood A. Khan, “Implications of Green Tea and Its Constituents in the Prevention of Cancer via the Modulation of Cell Signalling Pathway,” BioMed Research International, vol. 2015, pp. 1–12, 2015. View at Publisher · View at Google Scholar
  • Steven G. Gray, “Epigenetics of Cisplatin Resistance,” Epigenetic Cancer Therapy, pp. 613–637, 2015. View at Publisher · View at Google Scholar
  • Axel Haferkamp, Jochen Rutz, Saira Justin, Frederik Roos, Wael Khoder, Igor Tsaur, Karen Nelson, Wolf O. Bechstein, Eva Juengel, Roman A. Blaheta, and Sebastian Maxeiner, “Sulforaphane inhibits proliferation and invasive activity of everolimus-resistant kidney cancer cells in vitro,” Oncotarget, vol. 7, no. 51, pp. 85208–85219, 2016. View at Publisher · View at Google Scholar
  • Ciro Menale, Stefania Crispi, and Maria Teresa Piccolo, “Advances in cancer therapy: Novel approaches in combined drug treatments,” Frontiers in Drug Design and Discovery, vol. 7, no. 1, pp. 84–138, 2016. View at Publisher · View at Google Scholar
  • Sang-Han Lee, and Yoon-Jin Lee, “Pro-oxidant activity of sulforaphane and cisplatin potentiates apoptosis and simultaneously promotes autophagy in malignant mesothelioma cells,” Molecular Medicine Reports, vol. 16, no. 2, pp. 2133–2141, 2017. View at Publisher · View at Google Scholar
  • Rokas Račkauskas, Dachen Zhou, Simonas Uselis, Kȩstutis Strupas, Ingrid Herr, and Peter Schemmer, “Sulforaphane sensitizes human cholangiocarcinoma to cisplatin via the downregulation of anti-apoptotic proteins,” Oncology Reports, vol. 37, no. 6, pp. 3660–3666, 2017. View at Publisher · View at Google Scholar
  • Fulvia Farabegoli, Marzia Govoni, Enzo Spisni, and Alessio Papi, “EGFR inhibition by (-)-epigallocatechin-3-gallate and IIF treatments reduces breast cancer cell invasion,” Bioscience Reports, vol. 37, no. 3, 2017. View at Publisher · View at Google Scholar
  • Kendra Royston, Neha Udayakumar, Kayla Lewis, and Trygve Tollefsbol, “A Novel Combination of Withaferin A and Sulforaphane Inhibits Epigenetic Machinery, Cellular Viability and Induces Apoptosis of Breast Cancer Cells,” International Journal of Molecular Sciences, vol. 18, no. 6, pp. 1092, 2017. View at Publisher · View at Google Scholar
  • Samantha L Martin, Rishabh Kala, and Trygve O Tollefsbol, “Mechanisms for inhibition of colon cancer cells by sulforaphane through epigenetic modulation of microRNA-21 and human telomerase reverse transcriptase (hTERT) down-regulation.,” Current cancer drug targets, 2017. View at Publisher · View at Google Scholar
  • Simone G.J. van Breda, and Theo M.C.M. de Kok, “Smart Combinations of Bioactive Compounds in Fruits and Vegetables May Guide New Strategies for Personalized Prevention of Chronic Diseases,” Molecular Nutrition & Food Research, pp. 1700597, 2017. View at Publisher · View at Google Scholar
  • Bidisha Paul, Kendra J. Royston, Yuanyuan Li, Matthew L. Stoll, Christine F. Skibola, Landon S. Wilson, Stephen Barnes, Casey D. Morrow, and Trygve O. Tollefsbol, “Impact of genistein on the gut microbiome of humanized mice and its role in breast tumor inhibition,” Plos One, vol. 12, no. 12, pp. e0189756, 2017. View at Publisher · View at Google Scholar
  • Ki Hyun Bae, Susi Tan, Atsushi Yamashita, Wei Xia Ang, Shu Jun Gao, Shu Wang, Joo Eun Chung, and Motoichi Kurisawa, “Hyaluronic acid-green tea catechin micellar nanocomplexes: Fail-safe cisplatin nanomedicine for the treatment of ovarian cancer without off-target toxicity,” Biomaterials, vol. 148, pp. 41–53, 2017. View at Publisher · View at Google Scholar
  • Vincenza Gianfredi, Samuele Vannini, Massimo Moretti, Milena Villarini, Nicola Luigi Bragazzi, Alberto Izzotti, and Daniele Nucci, “Sulforaphane and Epigallocatechin Gallate Restore Estrogen Receptor Expression by Modulating Epigenetic Events in the Breast Cancer Cell Line MDA-MB-231: A Systematic Review and Meta-Analysis,” Journal of Nutrigenetics and Nutrigenomics, pp. 126–135, 2017. View at Publisher · View at Google Scholar
  • Xin-Gang Cui, Yi Gao, Lu Chen, Hai Huang, Fa-Jun Qu, Xiu-Wu Pan, Lei Yin, Xi Liu, Dan-Feng Xu, Jian-Min Lv, Ming Chen, and Lin Li, “High expression of PDLIM5 facilitates cell tumorigenesis and migration by maintaining AMPK activation in prostate cancer,” Oncotarget, vol. 8, no. 58, pp. 98117–98134, 2017. View at Publisher · View at Google Scholar
  • Yifeng Gao, and Trygve Tollefsbol, “Combinational Proanthocyanidins and Resveratrol Synergistically Inhibit Human Breast Cancer Cells and Impact Epigenetic–Mediating Machinery,” International Journal of Molecular Sciences, vol. 19, no. 8, pp. 2204, 2018. View at Publisher · View at Google Scholar
  • Bidisha Paul, Yuanyuan Li, and Trygve Tollefsbol, “The Effects of Combinatorial Genistein and Sulforaphane in Breast Tumor Inhibition: Role in Epigenetic Regulation,” International Journal of Molecular Sciences, vol. 19, no. 6, pp. 1754, 2018. View at Publisher · View at Google Scholar
  • Navneet Dubey, Bou-Yue Peng, Chien-Min Lin, Peter Wang, Joseph Wang, Chun-Hao Chan, Hong-Jian Wei, and Win-Ping Deng, “NSC 95397 Suppresses Proliferation and Induces Apoptosis in Colon Cancer Cells through MKP-1 and the ERK1/2 Pathway,” International Journal of Molecular Sciences, vol. 19, no. 6, pp. 1625, 2018. View at Publisher · View at Google Scholar
  • Samantha L. Martin, Kendra J. Royston, and Trygve O. Tollefsbol, “The Role of Non-Coding RNAs and Isothiocyanates in Cancer,” Molecular Nutrition & Food Research, pp. 1700913, 2018. View at Publisher · View at Google Scholar
  • Gordana Supic, Katarina Zeljic, and Zvonko Magic, “Epigenetic Nutraceuticals in Cancer Treatment,” Therapeutic Foods, pp. 449–493, 2018. View at Publisher · View at Google Scholar
  • Lidia Mielczarek, ZdzisŁaw Chilmonczyk, Piotr Suchocki, Piotr Wroczy-ski, and Katarzyna Wiktorska, “Combinations of isothiocyanates with drugs - A chance or threat to chemoprevention and cancer treatment?,” Acta Poloniae Pharmaceutica - Drug Research, vol. 75, no. 4, pp. 829–841, 2018. View at Publisher · View at Google Scholar
  • Mohammad Mirza Aghazadeh Attari, Caspian Ostadian, Amir Ata Saei, Ainaz Mihanfar, Saber Ghazizadeh Darband, Shirin Sadighparvar, Mojtaba Kaviani, Hossein Samadi, Bahman Yousefi, and Maryam Majidinia, “DNA damage response and repair in ovarian cancer: Potential targets for therapeutic strategies,” DNA Repair, 2019. View at Publisher · View at Google Scholar
  • Francesco Di Meo, Riccardo Aversano, Gianfranco Diretto, Olivia Costantina Demurtas, Clizia Villano, Salvatore Cozzolino, Stefania Filosa, Domenico Carputo, and Stefania Crispi, “Anti-cancer activity of grape seed semi-polar extracts in human mesothelioma cell lines,” Journal of Functional Foods, vol. 61, pp. 103515, 2019. View at Publisher · View at Google Scholar