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Journal of Oncology
Volume 2014, Article ID 614291, 3 pages
http://dx.doi.org/10.1155/2014/614291
Research Article

Incidence of Mast Cells in Oral Squamous Cell Carcinoma: A Short Study

1Department of Oral Pathology, St Joseph Dental College & Hospital, Duggirala, Eluru 534003, India
2Anuradha ENT Hospital, D/No-10/200, Eluru Road, Gudivada, Krishna District, Andhra Pradesh 521301, India

Received 12 September 2013; Revised 15 November 2013; Accepted 17 November 2013; Published 23 January 2014

Academic Editor: James L. Mulshine

Copyright © 2014 A. Anuradha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mast cells are regarded as complex and multifunctional cells, playing a significant role in immunopathology and a substantial role in tumor angiogenesis. Angiogenesis is a complex process that is tightly regulated by various growth factors in which mast cells act directly by releasing angiogenic factors and henceforth promoting tumor growth and metastasis. The aim of this study is to evaluate the number of mast cells in tissue sections of oral squamous cell carcinoma (OSCC) in comparison with normal mucosa. A total of 40 cases (20 OSCC and 20 normal mucosa) were stained with 1% toluidine blue and the quantitative analysis was done by using light microscope under 400x magnification. A significant increase in the mast cell count was observed in the sections of OSCC when compared to normal mucosa suggesting their contributing role in tumor growth and progression.