Dissecting the Potential Interplay of DEK Functions in Inflammation and Cancer

Figure 2

A summary of the roles of DEK in inflammation and tumorigenesis. DEK promotes inflammatory processes like persistent viral infection and autoimmune diseases, possibly through NFκB signaling (left). High DEK levels also promote tumor growth, metastasis, chemotherapeutic response, and an overall poor prognosis, which correlates with the activity of many oncogenic molecular mechanisms including Wnt/β-catenin, mTOR, Rho, and NFκB signaling as well as regulating expression of p53 family members (right). Chronic inflammation, supported by DEK expression, may promote tumorigenesis.