Research Article

Low Level of Microsatellite Instability Correlates with Poor Clinical Prognosis in Stage II Colorectal Cancer Patients

Table 3

Clinicopathological features of the study population according to MSI status.

TotalMSI-HMSI-LMSS value
(%) (%) (%)

Patients15835 (22.2)21 (13.3)102 (64.55)

Mean age Years50.3249.653.160.155

GenderFemale8211 (31.4)11 (52.4)60 (58.8)0.019
Male7624 (68.6)10 (47.6)42 (41.2)

Location of tumorColon9227 (77.1)11 (52.4)54 (52.9)0.030
Rectum668 (22.9)10 (47.6)48 (47.1)

DifferentiationWell648 (22.9)9 (42.9)47 (46.1)0.003
Moderately518 (22.9)7 (33.3)36 (35.3)
Poorly3919 (54.3)5 (23.8)19 (18.6)

TNM stageI213 (8.6)2 (9.5)16 (15.7)0.028
II7311 (31.4)10 (47.6)52 (51.0)
III5721 (60.0)8 (38.1)28 (27.5)
IV71 (4.8)6 (5.9)

T stage (T1 : T2 : T3 : T4)4 (11.4) : 2 (5.7) : 29 (82.9) : —1 (4.8) : 2 (9.5) : 15 (71.4) : 3 (14.3)16 (15.7) : 11 (10.8) : 66 (64.7) : 9 (8.8)0.104

N stage (N0 : N1 : N2)14 (40.0) : 17 (48.6) : 4 (11.4)12 (57.1) : 7 (33.3) : 2 (9.5)71 (69.6) : 25 (24.5) : 6 (5.9)0.043

M stage (M0 : M1)35 (100) : —20 (95.2) : 1 (4.8)96 (94.1) : 6 (5.6)0.162

Family historyYes7024 (68.5)9 (42.9)37 (36.3)<0.0001
No8811 (31.4)12 (57.1)65 (63.7)

Adjuvant therapyYes392 (10.5)7 (33.3)30 (29.4)0.054
No11933 (94.3)14 (66.7)72 (70.6)

Vital statusLiving14132 (91.4)17 (81.0)92 (90.2)0.463
Deceased173 (8.6)4 (19.0)10 (9.8)

Age of diagnosis<508914 (40.0)15 (71.4)60 (58.8)0.049
>506921 (60.0)6 (26.6)42 (41.2)

MetastasesYes292 (5.7)4 (19.0)23 (22.5)0.050
No12933 (94.3)17 (81.0)79 (77.5)