Research Article
Clinical Performance and Management Outcomes with the DecisionDx-UM Gene Expression Profile Test in a Prospective Multicenter Study
Table 1
CLEAR registry patient characteristics.
| | | Class 1 () | Class 2 () | p value |
| | Gender: | | | | | Female, n (%) | 13 (35%) | 24 (73%) | 0.002 | | Male, n (%) | 24 (65%) | 9 (27%) | |
| | Age at diagnosis (yrs) | | | | | Mean | 60.5 | 62.7 | 0.52 | | Median | 62 | 63 | | | Range | 29–84 | 31–87 | |
| | Ciliary body involvement, n (%) | 15 (41%) | 12 (36%) | 0.81 |
| | Tumor diameter (mm) | | | | | ≤10 (% of row) | 11 (73%) | 4 (27%) | | | >10 to ≤15 (% of row) | 15 (58%) | 11 (42%) | | | >15 (% of row) | 11 (38%) | 18 (62%) | | | Mean (SD) | 12.8 (1.84) | 15.64 (4.95) | 0.02 |
| | Tumor thickness (mm) | | | | | ≤3 (% of row) | 9 (69%) | 4 (31%) | | | >3 to ≤8 (% of row) | 18 (54%) | 15 (46%) | | | >8 (% of row) | 10 (42%) | 14 (58%) | | | Mean (SD) | 5.89 (3.34) | 7.02 (3.39) | 0.16 |
| | Treatment type | | | | | Enucleation | 9 (24%) | 17 (52%) | 0.026 | | Plaque radiotherapy | 23 (62%) | 11 (33%) | 0.019 | | Proton beam | 3 (8%) | 1 (3%) | 0.61 | | TTT | 0 (0%) | 1 (3%) | 0.47 | | None | 2 (5%) | 3 (9%) | 0.62 |
| | Follow-up (years) | | | | | Mean | 2.7 | 2.5 | 0.62 | | Median | 2.6 | 2.0 | |
| | Metastatic events, n (%) | 2 (5%) | 12 (36%) | 0.002 |
| | High-intensity management | 7 (19%) | 33 (100%) | |
| | Referrals | 4 (11%) | 11 (33%) | 0.04 | | Medical oncology | 4 (11%) | 6 (18%) | | | Clinical trials | 0 (0%) | 8 (24%) | |
| | Systemic adjuvant therapy | 0 (0%) | 4 (12%) | 0.04 |
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TTT: transpupillary thermotherapy.
Fisher’s exact test; Student’s t-test.
Liver function tests and/or imaging every 3–6 months.
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