Review Article

ErbB Proteins as Molecular Target of Dietary Phytochemicals in Malignant Diseases

Table 3

Curcumin in animal studies.

Animal modelTreatmentMain resultsRef

EGFR overexpressing A431 epidermoid carcinoma xenograft in nude mice0.5 mg curcumin i.p. twice a day and 1 h visible light exposure after treatmentErbB1 phosphorylation reduction;
decreased tumor growth through proliferation reduction by 70% and 4-fold increased apoptosis
[101]
Erlotinib resistant ErbB1 mutant NSCLC xenograft in nude mice1 g/kg body weight curcumin, oral
10 mg/kg erlotinib
Curcumin reduced ErbB1 expression and induced apoptosis
Curcumin alone decreased tumor growth and increased erlotinib effect on tumor growth reduction
[102]
ErbB1 expressing LNCaP xenograft in nude mice2% curcumin in dietCurcumin decreased tumor volume, decreased mitosis, increased apoptosis, and inhibited tumor angiogenesis[103]
ErbB2 overexpressing BT-474 breast cancer xenograft in nude mice45 mg/kg curcumin i.p. twice per week for 4 consecutive weeksCurcumin reduced the expression level of ErbB2, p-Akt, p-MAPK, and NF-κB; curcumin decreased tumor volume by 76.7%[20]