ErbB Proteins as Molecular Target of Dietary Phytochemicals in Malignant Diseases

Table 5

Bioavailability of EGCG.

Species	Route	Dose	Plasma/tissue		AUC	Ref
Rat	i.v.	10 mg/kg	Plasma	4.7 ± 0.9 μg/mL	143.2 ± 32.1 min⋅μg/mL	[117]
	i.g.	75 mg/kg	Plasma	19.8 ± 3.5 ng/mL	17.4 ± 7.0 min⋅μg/mL
Rat	i.v.	10 mg/kg	Plasma	12269.5 ± 2131.8 μg/L	2772.2 ± 479.9 h⋅μg/L	[118]
	Oral	100 mg/kg	Plasma	11.0 ± 5.9 μg/L	39.6 ± 14.2 h⋅μg/L
Mice	i.v.	21.8 μmol/kg	Plasma	13.6 ± 2.0 μmol/L	38.4 ± 5.6 min⋅μmol/L	[119]
			Prostate	0.31 ± 0.08 nmol/g	56.1 ± 16.0 min⋅μmol/L
			Lung	2.66 ± 1.0 nmol/g	91.0 ± 37.3 min⋅μmol/L
			Spleen	0.83 ± 0.22 nmol/g	31.7 ± 9.2 min⋅μmol/L
			Liver	3.56 ± 0.8 nmol/g	324.0 ± 79.5 min⋅μmol/L
			Kidney	2.12 ± 0.6 nmol/g	55.0 ± 17.0 min⋅μmol/L
			Small intestine	2.40 ± 1.1 nmol/g	114.0 ± 51.8 min⋅μmol/L
			Colon	1.20 ± 0.3 nmol/g	325.3 ± 88.7 min⋅μmol/L
	i.g.	163.8 μmol/kg	Plasma	0.04 ± 0.01 μmol/L	45.6 ± 13.5 min⋅μmol/L
Human	Oral	2 mg/kg	Plasma	34.71 _ 22.87 ng/mL	213.7 ± 86.4 h⋅ng/mL	[129]
Human	Oral	95 mg	Plasma	NA	857 h⋅ng/mL	[131]
Human	Oral	200 mg	Plasma	73.7 ± 25.3 ng/mL	22.5 ± 7.3 min⋅mg/mL	[130]
	Oral	400 mg	Plasma	111.8 ± 98.6 ng/mL	35.4 ± 21.5 min⋅mg/mL
	Oral	600 mg	Plasma	169.1 ± 139.6 ng/mL	101.9 ± 99.7 min⋅mg/mL
	Oral	800 mg	Plasma	438.5 ± 284.4 ng/mL	167.1 ± 57.0 min⋅mg/mL

i.v.: intravenous; i.g.: intragastric; , maximum concentration; AUC, area under the curve.