Review Article

Desired Turbulence? Gut-Lung Axis, Immunity, and Lung Cancer

Table 2

Most frequently detected bacteria in the lung of patients suffering from their respective diseases. Results from different studies were presented by the taxa level in which they were originally detected, in order of decreasing abundance where possible. If the sampling, analysis method, or result was specific for a certain study, the reference was added adjacent to the corresponding information.

DiseaseSample sourcePhylumOrder or familyGenus or speciesReference
Analysis method

LungCOPDBAL, sputum,
lung tissue   
16S sequencing, qPCR/DGGE,
bacterial culture
Proteobacteria (44%) and Firmicutes (16%) followed by Actinobacteria (13%), with Bacteroidetes,Fusobacteria, Tenericutes,SR1 incertae, TM7, and Synergistetes identified in lower proportions (<3%) [18]
Increase in Proteobacteria(sometimes Firmicutes), decrease in Bacteroidetesand Firmicutes [19]
In moderate COPD mostly Actinobacteria and Proteobacteria 
In severe COPD mostly Actinobacteria and Firmicutes [16]
Proteobacteria, Bacteroidetes, Firmicutes, Actinobacteria, and Fusobacteria [7]
Haemophilus influenza, Pseudomonas aeruginosa, Moraxella catarrhalis, and Streptococcus pneumoniae [18]
Significant increases of Streptococcus pneumoniae, Klebsiella pneumoniae, and Pseudomonas aeruginosa [20]
Streptococcus, Abiotrophia, Rothia, Tropheryma, Actinomyces, Peptostreptococcus, Serratia, Capnocytophaga, Leptotrichia, Kingella, and Dysgonomonas [16]
Significant abundance of Pseudomonas and Haemophilus [17]
Prevotella, Haemophilus, Streptococcus, Neisseria, other Proteobacteria, Veillonella, other Firmicutes, other Bacteroidetes, Fusobacterium, other Actinobacteria, and Staphylococcus [7]
Erb-Downward et al. [17]
Garcia-Nuñez et al. [18]
Hilty et al. [7]
Sze et al. [19]
Wu et al. [20]
Pragman et al. [16]
Lung cancerSputum, saliva  
anaerobic culture,
16S sequencing
Flavobacteriales, Burkholderiales, Campylobacterales, Spirochaetales(more abundant), and Bacteroidales(less abundant) [21]
Veillonellaceae significantly overexpressed whereas Lachnospiraceae underexpressed [21]
Actinomyces spp., Peptostreptococcus spp., Eubacterium lentum, Veillonella parvula, Prevotella spp., Bacteroides spp., Lactobacillus jensenii [22]
Capnocytophaga, Selenomonas, and Veillonella were found to be more abundant in both SCC and AC [21]
Rybojad et al. [22]
Yan et al. [21]

COPD: chronic obstructive pulmonary disease; BAL: bronchoalveolar lavage; DGGE: PCR-denaturing gradient gel electrophoresis; SCC: small cell carcinoma; AC: adenocarcinoma.