The Prognostic Role of NEDD9 and P38 Protein Expression Levels in Urinary Bladder Transitional Cell Carcinoma
Table 1
Clinicopathological features, immunohistochemical markers, and outcome of 50 patients with TCC of bladder.
Characteristics
All
NEDD9
value
P38
value
Low ()
High ()
Low ()
High ()
()
Number
(%)
Number
(%)
Number
(%)
Number
(%)
Number
(%)
Age (years)
Mean ± SD
55.08 ± 10.36
55.2 ± 12.37
54.96 ± 9.37
51.75 ± 10.26
59.31 ± 9.03
Median (range)
52
(35–75)
56
(35–72)
50
(43–75)
49
(35–72)
61
(43–75)
≤60 years
32
(64%)
10
(58.8%)
22
(66.7%)
21
(75%)
11
(50%)
>60 years
18
(36%)
7
(41.2%)
11
(33.3%)
7
(25%)
11
(50%)
Sex
Male
35
(70%)
5
(29.4%)
30
(90.9%)
<
13
(46.4%)
22
(100%)
<
Female
15
(30%)
12
(70.6%)
3
(9.1%)
15
(53.6%)
0
(0%)
Size (cm)
Mean ± SD
3.74
±2.74
2.35
±1.49
4.45
±2.0
2.89
±2.42
4.81
±2.80
Median (range)
2
(1–10)
2
(1–6)
2.98
(1–10)
2
(1–10)
6
(1–9)
≤5 cm
34
(68%)
16
(94.1%)
18
(54.5%)
24
(85.7%)
10
(45.5%)
>5 cm
16
(32%)
1
(5.9%)
15
(45.5%)
4
(14.3%)
12
(54.5%)
Multiplicity
Absent
17
(34%)
17
(100%)
0
(0%)
<
14
(50%)
3
(13.6%)
Present
33
(66%)
0
(0%)
33
(100%)
14
(50%)
19
(86.4%)
Grade
Low grade
13
(26%)
13
(76.5%)
0
(0%)
<
13
(46.4%)
0
(0%)
<
High grade
37
(74%)
4
(23.5%)
33
(100%)
15
(53.6%)
22
(100%)
Deep invasion
Absent
24
(48%)
16
(94.1%)
8
(24.2%)
<
22
(78.6%)
2
(9.1%)
<
Present
26
(52%)
1
(5.9%)
25
(75.8%)
6
(21.4%)
20
(90.9%)
T
Ta
5
(10%)
5
(29.4%)
0
(0%)
<
5
(17.9%)
0
(0%)
<
T1
19
(38%)
11
(64.7%)
8
(24.2%)
17
(60.7%)
2
(9.1%)
T2
22
(44%)
1
(5.9%)
21
(63.6%)
6
(21.4%)
16
(72.7%)
T3
4
(8%)
0
(0%)
4
(12.1%)
0
(0%)
4
(18.2%)
Lymph node
Negative
36
(72%)
16
(94.1%)
20
(60.6%)
27
(96.4%)
9
(40.9%)
<
Positive
14
(28%)
1
(5.9%)
13
(39.4%)
1
(3.6%)
13
(59.1%)
NEDD9
Mean ± SD
34.54 ± 24.15
8.64 ± 4.83
47.87 ± 18.49
<
26.85 ± 24.43
44.31 ± 20.37
Median (range)
30
(3–90)
7
(3–20)
50
(20–90)
20
(3–90)
50
(5–80)
Low
17
(34%)
14
(50%)
3
(13.6%)
High
33
(66%)
14
(50%)
19
(86.4%)
P38
Mean ± SD
44.1 ± 28.17
30.29 ± 24.71
51.21 ± 27.50
20.53 ± 7.24
74.09 ± 10.07
<
Median (range)
30
(10–90)
20
(10–90)
60
(10–90)
20
(10–35)
70
(60–90)
Low
28
(56%)
14
(82.4%)
14
(42.4%)
High
22
(44%)
3
(17.6%)
19
(57.6%)
Categorical variables were expressed as number (percentage); continuous variables were expressed as mean ± SD and median (range). –Whitney test; -square test; -square test for trend; is significant.
