Research Article
S100A4 May Be a Good Prognostic Marker and a Therapeutic Target for Colon Cancer
Table 1
The Association between the S100A4 expression status, the staining status of the tumor tissue, and clinicopathologic variables.
(a) S100A4 expression. |
| Clinicopathologic features | Variables | Absent | Present | Total | Chi-square Test | n | % | n | % | n | % | p |
| TNM Stage | I | 5 | 31.3 | 6 | 4.6 | 11 | 7.4 | 0.001 | II | 9 | 56.3 | 55 | 41.7 | 64 | 43.2 | III | 0 | 0 | 38 | 28.8 | 38 | 25.7 | IV | 2 | 12.5 | 33 | 25 | 35 | 23.7 |
| Duration of Survival | < 2 years | 5 | 31.3 | 95 | 72 | 100 | 67.6 | 0.003 | 2-5 years | 3 | 18.3 | 17 | 12.9 | 20 | 13.5 | 5-10 years | 8 | 50 | 20 | 15.2 | 28 | 18.9 |
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(b) Distribution of tumor tissue staining. |
| Clinicopathologic features | Variables | Absent | Superficial | Deep | Complete | Total | Chi-square Test | n | % | n | % | n | % | n | % | n | % | p |
| Age Groups | < 60 years | 4 | 25 | 22 | 55 | 10 | 66.7 | 28 | 36.4 | 64 | 43.2 | 0.026 | > 60 years | 12 | 75 | 18 | 45 | 5 | 33.3 | 49 | 63.6 | 84 | 56.8 |
| Colon-Tumor Localization | Right | 9 | 56.3 | 23 | 57.5 | 5 | 33.3 | 37 | 48.1 | 74 | 50 | 0.003 | Transverse | 0 | 0 | 5 | 12.5 | 3 | 20 | 18 | 23.4 | 26 | 17.6 | Left | 4 | 25 | 7 | 17.5 | 1 | 6.7 | 10 | 13 | 22 | 14.9 | Sigmoid | 0 | 0 | 3 | 7.5 | 0 | 0 | 9 | 11.7 | 12 | 8.11 | Multicentric | 3 | 18.6 | 2 | 5 | 6 | 40 | 3 | 3.9 | 14 | 9.46 |
| TNM Stage | I | 5 | 31.3 | 4 | 10 | 0 | 0 | 2 | 2.6 | 11 | 7.43 | 0.001 | II | 9 | 56.3 | 25 | 62.5 | 8 | 53.3 | 22 | 28.6 | 64 | 43.2 | III | 0 | 0 | 4 | 10 | 3 | 20 | 31 | 40.3 | 38 | 25.7 | IV | 2 | 12.5 | 7 | 17.5 | 4 | 26.7 | 22 | 28.6 | 35 | 23.65 |
| Duration of Survival | < 2 years | 5 | 31.3 | 28 | 70 | 8 | 53.3 | 59 | 76.6 | 100 | 67.6 | 0.002 | 2-5 years | 3 | 18.8 | 2 | 5 | 4 | 26.7 | 11 | 14.3 | 20 | 13.5 | 5-10 years | 8 | 50 | 10 | 25 | 3 | 20 | 7 | 9.09 | 28 | 18.9 |
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