Journal of Oncology / 2018 / Article / Tab 5

Research Article

The De Ritis and Neutrophil-to-Lymphocyte Ratios May Aid in the Risk Assessment of Patients with Metastatic Renal Cell Carcinoma

Table 5

Comparison of new risk models for overall survival using the Heng and MSKCC risk models with 2000 bootstraps.

ModelHarrell’s C indexmean(difference), 95% CI (2.5%, 97.5% of difference)

Model A0.708Model B vs A: 0.02 (-0.011, 0.058)
Model B0.727

Heng risk model0.661Heng vs Model A: -0.035 (-0.088, 0.008)
Heng vs Model B: -0.055 (-0.112, -0.004)
mMSKCC risk model0.612mMSKCC vs Model A: -0.097 (-0.153, -0.043)
mMSKCC vs Model B: -0.117 (-0.174, -0.066)

Model C = Heng risk model + AST0.676Heng vs (Heng + SGOT): -0.011 (-0.031, 0.004)
Model D = Heng risk model + Alkaline phosphatase + DRR0.697Heng vs (Heng + De Ritis ratio): -0.035 (-0.083, 0)
(Heng + SGOT) vs (Heng + De Ritis ratio): -0.024 (-0.07, 0.011)

Model E = mMSKCC risk model + Neutrophil + AST0.658mMSKCC vs Model E: -0.049 (-0.098, -0.013)
Model F = mMSKCC risk model + NLR + Alkaline phosphatase +DRR0.691mMSKCC vs Model F: -0.084 (-0.149, -0.034)
Model E vs Model F: -0.034 (-0.092, 0.014)

MSKCC, Memorial Sloan Kettering Cancer Center; AST, aspartate transaminase; NLR, neutrophil-to-lymphocyte ratio; CI, confidence interval.
Model A = Nephrectomy, Liver mets, Hb, Neutrophil, Alkaline phosphatase.
Model B = Nephrectomy, Hb, NLR, Alkaline phosphatase, DRR.

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