The Association of Simultaneous Increase in Interleukin-6, C Reactive Protein, and Matrix Metalloproteinase-9 Serum Levels with Increasing Stages of Colorectal Cancer

Table 1

IL-6, CRP, and MMP-9 serum concentrations in relation to clinicopathological features of the colorectal cancer.

		CRC stage
Variabe	Control; (n=20)	II; (n=22)	III; (n=27)	IV; (n=26)	p Value
IL-6; (pg/mL)	0.0; (0.0-0.0	2.5; (0.0-4.0	6.5; (0.2-21.3	28.8; (10.4-75.6	<0.001
CRP; (mg/L)	2.3; (0.7-3.8	7.2; (2.3-13.0	19.0; (8.5-45.0	38.6; (21.4-74.5	<0.001
MMP-9; (ng/mL)	310.6; (205.0-356.3	434.8; (373.3-447.4	458.4; (447.0-464.1	459.7; (453.2-469.6	<0.001
		Bowel wall infiltration (pT)
		pT2; (n=10)	pT3; (n=38)	pT4; (n=27)	p Value
IL-6; (pg/mL)	0.0; (0.0-0.0	6.6; (0.3-21.1	8.9; (2.1-29.2	6.5; (0.2-21.3	0.306
CRP; (mg/L)	2.3; (0.7-3.8	17.75; (7.3-20.25	19.9; (7.9-45.7	29.7; (14.7-50	<0.05
MMP-9; (ng/mL)	310.6; (205.0-356.3	450.35; (438-454.8	450.9; (435.8-460.5	458.4; (447-464.1	0.103
		Lymph nodes invasion (pN)
		pN0 (n=25)	pN1 (n=26)	pN2 (n=24)	p Value
IL-6; (pg/mL)	0.0; (0.0-0.0	3.0; (0.0-5.2	10.3; (2.5-44.8	20.1; (6.4-46.7	<0.001
CRP; (mg/L)	2.3; (0.7-3.8	8.3; (2.4-20.3	26.7; (15.9-59.3	33.7; (14.7-68.5	<0.001
MMP-9; (ng/mL)	310.6; (205.0-356.3	437.4; (383.3-448.8	458.9; (452.8-465.4	458.2; (449.8-464.6	<0.001

Data are presented as median and interquartile range q1-q3 (25%-75%).
Values in the same row that do not contain a common lettering differ significantly on the level p <0.05.
CRC: colorectal cancer; IL-6: interleukin-6; CRP: C-reactive protein; MMP-9: matrix metalloproteinase-9; pT2: tumor invades muscularis propria; pT3: the tumor invades through the muscularis propria in the pericolic tissue; pT4: the tumor penetrates the surface of visceral peritoneum or other organs; pN0: no invasion to regional lymph nodes; pN1: 1-3 regional metastatic lymph nodes; pN2: 4 or more metastatic lymph nodes.