Advancing Parental Age and Risk of Solid Tumors in Children: A Case-Control Study in Peru
Table 4
Effect of paternal age in childhood solid cancers development.
Diagnosis
Paternal age
N
Unadjusted OR
CI 95
Adjusted OR
CI 95
Brain tumor
All ages
62
p-value=0.94a
p-value=0.98
<20
5
0.44
0.02-4.57
0.33
0.02-3.89
20-24
16
1.12
0-42-3.01
1.01
0.36-2.83
25-29b
14
1
1
30-34
18
0.90
0.33-2.4
0.91
0.30-2.73
>35
9
0.90
0.36-2.19
0.99
0.34-2.85
Non-Hodgkin lymphoma
All ages
43
p-value=0.09
p-value=0.047
<20
1
-
-
20-24
11
0.24
0.06-0.96
0.19
0.03-0.97
25-29b
13
1
1
30-34
13
0.54
0.17-1.73
0.37
0.09-1.43
>35
5
0.48
0.17-1.34
0.36
0.82-1.64
Osteosarcoma
All ages
42
p-value=0.10
p-value=0.23
<20
3
-
-
20-24
16
5.70
0.98-33.0
3.10
0.94-8.6
25-29b
10
1
1
30-34
8
1.80
0.55-5.24
1.15
0.32-4.05
>35
5
1.35
0.46-3.97
0.92
0.27-3.1
Wilms tumor
All ages
35
p-value=0.31
p-value=0.39
<20
1
-
-
20-24
10
0.41
0.06-2.61
0.36
0.05-2.51
25-29b
5
1
1
30-34
9
1.05
0.26-4.17
1.30
0.30-5.59
>35
10
1.43
0.42-4.92
2.06
0.41-10.16
Ewing’s sarcoma
All ages
24
p-value=0.36
p-value=0.52
<20
2
-
-
20-24
7
1.01
0.14-7.12
1.00
0.13-7.22
25-29b
7
1
1
30-34
3
0.89
0.24-3.23
0.66
0.13-3.37
>35
5
0.38
0.07-1.88
0.25
0.03-2.01
Soft tissue sarcoma
All ages
24
p-value=0.43
p-value=0.38
<20
0
-
-
20-24
6
0.33
0.28-4.11
0.91
0.4-18.3
25-29b
7
1
1
30-34
6
0.48
0.11-2.02
0.76
0.13-4.3
>35
5
0.42
0.12-1.45
0.25
0.02-1.86
Gonadal germinal tumor
All ages
21
p-value=0.03
p-value=0.04
<20
1
-
-
20-24
8
2.74
0-35-20.41
2.09
0.16-26.03
25-29b
3
1
1
30-34
6
1.52
1.29-19.4
5.71
1.76-14.41
>35
3
1.37
0.22-8.53
5.82
0.32-10.36
Retinoblastoma
All ages
16
p-value=0-03
p-value=0.005
<20
0
20-24
5
1.96
0.39-4.34
3.37
0.24-4.81
25-29b
3
1
1
30-34
3
2.11
0.28-15.75
1.37
0.59-12.19
>35
5
2.10
1.21-15.04
1.17
1.01-16.33
Hepatoblastoma
All ages
16
p-value=0.16
p-value=0.21
<20
1
-
-
20-24
2
-
-
25-29b
3
1
1
30-34
4
0.18
0.017-1.96
0.10
0.01-1.55
>35
6
0.21
0.02-2.11
0.10
0.01-1.80
Hodgkin lymphoma
All ages
14
p-value=0.97
p-value=0.47
<20
2
0.72
0.03-16.01
0.24
0.01-11.58
20-24
6
1.25
0.15-10.43
0.50
0.02-8.60
25-29b
2
1
1
30-34
4
0.52
0.03-7.16
0.89
0.06-12.85
>35
0
1.59
0.16-15.7
1.96
0.13-28.8
Neuroblastoma
All ages
12
p-value=0.13
p-value=0.48
<20
1
-
-
20-24
1
5.26
0.13-19.05
5.4
0.12-22.24
25-29b
5
1
1
30-34
4
3.10
0.21-45.23
2.08
0.17-35.38
>35
1
0.54
0.06-4.33
0.28
0.01-4.38
Adjusted by maternal age, number of siblings, and level of maternal and paternal education. Significant results are bolded. a denotes where age groups are taken to be continuous in all cancers. b denotes reference group.
