Journal of Oncology / 2018 / Article / Fig 1

Research Article

Exploration of the Combination of PLK1 Inhibition with Immunotherapy in Cancer Treatment

Figure 1

PLK1 likely inversely correlates with immune cell infiltration and immune activities in cancer. (a) The PLK1 expression levels inversely correlate with immune scores in 10 cancer types and positively correlate with immune scores in 4 cancer types (Spearman correlation, FDR<0.1). (b) The PLK1 expression levels inversely correlate with B cell infiltration in 13 cancer types and positively correlate with B cell infiltration in 5 cancer types (Spearman correlation, FDR<0.1). (c) Most of the B cell gene signatures show negative expression correlations with the PLK1 expression in ESCA, LUSC, and STAD (Pearson correlation, FDR<0.1). (d) The PLK1 expression levels inversely correlate with NK cell infiltration in 6 cancer types and positively correlate with NK cell infiltration in 1 cancer type (Spearman correlation, FDR<0.1). (e) The PLK1 expression levels inversely correlate with TILs infiltration in 9 cancer types and positively correlate with TILs infiltration in 4 cancer types (Spearman correlation, FDR<0.1). R: Spearman or Pearson correlation coefficient. FDR: false discovery rate. NK: natural killer. TILs: tumor-infiltrating lymphocytes.
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