Outcomes Following Salvage Radiation and Systemic Therapy for Isolated Locoregional Recurrence of Breast Cancer after Mastectomy: Impact of Constructed Biologic Subtype

Table 5

Multivariate analysis of prognostic factors for outcomes after postmastectomy ILRR.

Parameter	LRC			DMFS			DFS			OS
	HR	95% CI	P-value	HR	95% CI	P-value	HR	95% CI	P-value	HR	95% CI	P-value
Nodal stage
Node-positive versus node-negative				1.65	1.19-2.27	0.002	1.62	1.18-2.23	0.003	1.72	1.19-2.48	0.001
Biologic subtype			0.001			0.001			0.001			0.001
Rec+/HER2-
Rec+/HER2+	1.48	0.56-3.88	0.424	2.28	1.31-3.98	0.004	2.10	1.23-3.61	0.009	3.09	1.68-5.71	0.001
Rec-/HER2+	1.95	0.73-5.18	0.181	3.91	2.33-6.58	0.001	3.55	2.16-5.83	0.001	5.77	3.25-10.22	0.001
Rec-/HER2-	4.36	2.32-8.20	0.001	4.28	2.85-6.44	0.001	3.92	2.64-5.84	0.001	8.55	5.40-13.52	0.001
Disease-free interval (years)
≤ 2 versus >2				0.95	0.68-1.32	0.773	0.97	0.70-1.36	0.891	0.84	0.58-1.23	0.387
Regional recurrence
Yes vs. no				2.03	1.06-3.41	0.033	1.59	1.04-2.69	0.045	1.41	1.02-2.50	0.052
Radical surgery for ILRR
Yes versus No	0.37	0.18-0.82	0.009	0.67	0.34-1.32	0.256	0.64	0.41-1.02	0.063	0.74	0.44-1.24	0.253
Irradiated volume
CW or regional nodes
CW + regional nodes	0.26	0.14-0.49	0.001
Systemic treatment after ILRR
Yes versus No	0.63	0.21-1.84	0.402	0.67	0.34-1.32	0.255	0.64	0.32-1.27	0.202	0.56	0.29-1.09	0.082

HR = hazard ratio. Others as in Table 4.