TFF1 and TFF3 mRNAs Are Higher in Blood from Breast Cancer Patients with Metastatic Disease than Those without

Table 2

The performance analysis of TFF1 and TFF3 mRNA within metastatic and nonmetastatic groupsconsidered the value of 0.7 units as cut-off for both TFF1 mRNA and TFF3 mRNA above which samples were considered to have higher concentration and below which samples were considered to have low concentration.

Variables	AUC	Cut-off	Sensitivity; (95%CI)	Specificity; (95%CI)	PPV; (95%CI)	NPV; (95%CI)
TFF1	0.784	> 0.7	34.62; (17.2-55.7)	100.0; (85.8-100.0)	100.0; (66.4-100.0)	58.5; (42.1-73.7)
TFF3	0.671	> 0.7	46.15; (26.6-66.6)	83.33; (62.6-95.3)	75.0; (47.6-92.7)	58.8; (40.7-75.4)
Combined TFF1&TFF3	0.705	-------	57.69; (36.9-76.6)	83.3; (62.6-95.3)	78.9; (54.4-93.9)	64.5; (45.4-80.8)

AUC: area under the curve, PPV: positive predictive value, NPV: negative predictive value, and CI: confidence interval.