MiR-30a: A Novel Biomarker and Potential Therapeutic Target for Cancer

Figure 4

MiR-30a regulates target genes involved in cancer invasion and metastasis. Wnt signaling and PI3K/Akt pathways are major pathways to regulate cell invasion and metastasis. Partial target genes of miR-30a mediate EMT to control cell invasion and metastasis. In addition, Eya2, EYA2, DTL, IRS2, SEPT7, and Skp2 also mediate cancer cell invasion and migration. However, miR-30a promotes migratory and invasive abilities in glioma and pancreatic cancer cells.