Glucose and Lactate Transport in Pancreatic Cancer: Glycolytic Metabolism Revisited

Figure 1

Several signaling pathways lead to the expression of GLUT-1 in PDAC cells. These include canonical Ras and Src pathways in addition to the adaptive response to a hypoxic microenvironment. Other factors associated with GLUT-1 expression are represented that characterize the aberrant physiology of tumor cells.