Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma

Table 1

Differential gene expression in OSCC compared to adjacent non-tumor tissue.

Gene	Gene name	Gene ID
One Sample T test			Mean RQ	Std Dev	p value	p’ value	p – p’
CYP27A1	Cytochrome P450, Family 27, Subfamily A, Polypeptide 1	1593	0.4952	0.3721	0.0064	0.00323	0.003174
CYP2E1	Cytochrome P450, Family 2, Subfamily E, Polypeptide 1	1571	0.5111	0.387	0.0091	0.00484	0.004261
CYP2R1	Cytochrome P450, Family 2, Subfamily R, Polypeptide 1	120227	0.5472	0.4618	0.0276	0.00726	0.020342
CYP2J2	Cytochrome P450, Family 2, Subfamily J, Polypeptide 2	1573	0.4178	0.2963	0.0009	0.00081	0.000094
CYP2U1	Cytochrome P450, Family 2, Subfamily U, Polypeptide 1	113612	0.6086	0.4472	0.0425	0.00968	0.032823
CYP4F12	Cytochrome P450, Family 4, Subfamily F, Polypeptide 12	66002	0.4057	0.417	0.005	0.00242	0.002581
CYP4X1	Cytochrome P450, Family 4, Subfamily X, Polypeptide 1	260293	0.4639	0.4158	0.0082	0.00403	0.004168
PTGIS/ CYP8A1	Prostaglandin I2 (Prostacyclin) Synthase / Cytochrome P450, Family 8, Subfamily A, Polypeptide 1	5740	0.3479	0.3419	0.001	0.00161	-0.000613
Wilcoxon Signed Rank Test			Median RQ	75th per	p value	p’ value
ALOX12	Arachidonate 12-Lipoxygenase	239	0.03578	0.2277	0.0391	0.00806	0.031035
CYP27B1	Cytochrome P450, Family 27, Subfamily B, Polypeptide 1	1594	1.927	6.343	0.0391	0.00887	0.030229
CYP4B1	Cytochrome P450, Family 4, Subfamily B, Polypeptide 1	1580	0.08512	0.618	0.0234	0.00645	0.016948
MAOB	Monoamine Oxidase B	4129	0.1882	0.3693	0.0156	0.00565	0.009955

Gene Identification second-base gene data, the National Center for Biotechnology Information (NCBI, http://www.ncbi.nlm.nih.gov/gene); Standard Deviation; 75th Percentile; p’ value after Benjamini-Hochberg False Discovery Rate; p-p’ Statistical significance occurs when the p value of the individual tests is less than the p’ value after correction for multiple tests. Significance is only confirmed for negative result of the subtraction of these values (value p - value p’), emphasized in bold.