PPAR Enhances Cancer Cell Chemotherapy Sensitivity by Autophagy Induction

Figure 1

Silenced PPAR inhibits autophagy. (a) PPARα shRNA silenced SW480, Hela and 293T cell lysates were subjected to Western blot. (b) Representative images of GFP-LC3 puncta (autophagosomes) in PPARα silenced SW480 cells. Scar bar: 20 μm. The GFP-puncta was quantified. Results are expressed as means ± SEM (n=5). P<0.05. (c) TEM analysis of PPARα shRNA silenced SW480 cells. Arrows show the autophagosomes.

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