Research Article

HBV-DNA Load-Related Peritumoral Inflammation and ALBI Scores Predict HBV Associated Hepatocellular Carcinoma Prognosis after Curative Resection

Table 2

Independent risk factors predicting prognosis of HCC in training cohort.

VariablesUnivariate analysisMultivariate analysis
HR (95CI)P-valueHR (95CI)P-value

OS
Age-0.206NA
Gender-0.836NA
Cirrhosis-0.075NA
ALT-0.509NA
AST-0.057NA
TBIL-0.362NA
Platelet-0.283NA
HBsAg-0.623NA
Child-Pugh grade-0.386NA
Antiviral therapy0.863NA
Tumor capsule-0.076NA
GGT (U/L)1.678 (1.132-2.486)0.009_0.195
ALB (g/L)0.640 (0.432-0.950)0.026_0.443
AFP (≤20/>20 ng/ml)1.581 (1.041-2.399)0.030_0.190
Tumor number (single/multiple)2.299 (1.422-3.717)<0.0012.051 (1.266-3.321)0.004
Microvascular invasion (yes/no)2.132 (1.431-3.177)<0.0011.431 (1.042-2.015)0.046
Tumor size (≤3.0/>3.0 cm)2.881 (1.751-4.743)<0.0013.125 (2.079-3.884)<0.001
HBV-ALBI (I/II/III/IV)2.499 (1.109-3.342)0.0012.539 (1.056-3.217)0.007
HBV-PIS (I/II/III/IV)2.512 (1.335-3.718)0.0012.859 (1.207-3.623)0.004
RFS
Age-0.053NA
Gender-0.485NA
Cirrhosis-0.063NA
ALB-0.180NA
ALT-0.647NA
TBIL-0.713NA
Platelet-0.478NA
HBsAg-0.073NA
Child-Pugh grade-0.825NA
Antiviral therapy0.0160.112
Tumor capsule-0.170NA
AST (U/L)1.427 (1.048-1.943)0.023_0.237
GGT (U/L)1.464 (1.074-1.996)0.015_0.089
AFP (≤20/>20 ng/ml)1.679 (1.204-2.340)0.0021.458 (1.051-2.021)0.024
Tumor number (single/multiple)1.792 (1.183-2.713)0.0051.578 (1.054-2.363)0.027
Microvascular invasion (yes/no)2.197 (1.593-3.029)<0.0011.581 (1.136-2.199)0.007
Tumor size (≤3.0/>3.0 cm)1.548 (1.775-3.658)<0.0012.039 (1.404-2.962)<0.001
HBV-ALBI (I/II/III/IV)2.382 (1.582-2.816)0.0011.959 (1.112-2.785)0.006
HBV-PIS (I/II/III/IV)2.341 (1.464-2.544)<0.0012.008 (1.305-2.957)0.042

HCC: hepatocellular carcinoma; HR: hazard ratio; CI: confidence interval; ALT: alanine aminotransferase; AST: aspartate aminotransferase; TBIL: total bilirubin; HBsAg: hepatitis B virus surface antigen; GGT: gamma-glutamyl transpeptidase; ALB: Albumin; AFP: alpha-fetoprotein; HBV-PIS: hepatitis B virus load related peritumoral inflammatory score; HBV-ALBI: hepatitis B virus load related ALBI score. NA: no adopted