Research Article
HBV-DNA Load-Related Peritumoral Inflammation and ALBI Scores Predict HBV Associated Hepatocellular Carcinoma Prognosis after Curative Resection
Table 2
Independent risk factors predicting prognosis of HCC in training cohort.
| Variables | Univariate analysis | Multivariate analysis | HR (95CI) | P-value | HR (95CI) | P-value |
| OS | | | | | Age | - | 0.206 | | NA | Gender | - | 0.836 | | NA | Cirrhosis | - | 0.075 | | NA | ALT | - | 0.509 | | NA | AST | - | 0.057 | | NA | TBIL | - | 0.362 | | NA | Platelet | - | 0.283 | | NA | HBsAg | - | 0.623 | | NA | Child-Pugh grade | - | 0.386 | | NA | Antiviral therapy | | 0.863 | | NA | Tumor capsule | - | 0.076 | | NA | GGT (U/L) | 1.678 (1.132-2.486) | 0.009 | _ | 0.195 | ALB (g/L) | 0.640 (0.432-0.950) | 0.026 | _ | 0.443 | AFP (≤20/>20 ng/ml) | 1.581 (1.041-2.399) | 0.030 | _ | 0.190 | Tumor number (single/multiple) | 2.299 (1.422-3.717) | <0.001 | 2.051 (1.266-3.321) | 0.004 | Microvascular invasion (yes/no) | 2.132 (1.431-3.177) | <0.001 | 1.431 (1.042-2.015) | 0.046 | Tumor size (≤3.0/>3.0 cm) | 2.881 (1.751-4.743) | <0.001 | 3.125 (2.079-3.884) | <0.001 | HBV-ALBI (I/II/III/IV) | 2.499 (1.109-3.342) | 0.001 | 2.539 (1.056-3.217) | 0.007 | HBV-PIS (I/II/III/IV) | 2.512 (1.335-3.718) | 0.001 | 2.859 (1.207-3.623) | 0.004 | RFS | | | | | Age | - | 0.053 | | NA | Gender | - | 0.485 | | NA | Cirrhosis | - | 0.063 | | NA | ALB | - | 0.180 | | NA | ALT | - | 0.647 | | NA | TBIL | - | 0.713 | | NA | Platelet | - | 0.478 | | NA | HBsAg | - | 0.073 | | NA | Child-Pugh grade | - | 0.825 | | NA | Antiviral therapy | | 0.016 | | 0.112 | Tumor capsule | - | 0.170 | | NA | AST (U/L) | 1.427 (1.048-1.943) | 0.023 | _ | 0.237 | GGT (U/L) | 1.464 (1.074-1.996) | 0.015 | _ | 0.089 | AFP (≤20/>20 ng/ml) | 1.679 (1.204-2.340) | 0.002 | 1.458 (1.051-2.021) | 0.024 | Tumor number (single/multiple) | 1.792 (1.183-2.713) | 0.005 | 1.578 (1.054-2.363) | 0.027 | Microvascular invasion (yes/no) | 2.197 (1.593-3.029) | <0.001 | 1.581 (1.136-2.199) | 0.007 | Tumor size (≤3.0/>3.0 cm) | 1.548 (1.775-3.658) | <0.001 | 2.039 (1.404-2.962) | <0.001 | HBV-ALBI (I/II/III/IV) | 2.382 (1.582-2.816) | 0.001 | 1.959 (1.112-2.785) | 0.006 | HBV-PIS (I/II/III/IV) | 2.341 (1.464-2.544) | <0.001 | 2.008 (1.305-2.957) | 0.042 |
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HCC: hepatocellular carcinoma; HR: hazard ratio; CI: confidence interval; ALT: alanine aminotransferase; AST: aspartate aminotransferase; TBIL: total bilirubin; HBsAg: hepatitis B virus surface antigen; GGT: gamma-glutamyl transpeptidase; ALB: Albumin; AFP: alpha-fetoprotein; HBV-PIS: hepatitis B virus load related peritumoral inflammatory score; HBV-ALBI: hepatitis B virus load related ALBI score. NA: no adopted
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